ID A0A1F6VF70_9BACT Unreviewed; 676 AA.
AC A0A1F6VF70;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=A2738_02405 {ECO:0000313|EMBL:OGI68287.1};
OS Candidatus Nomurabacteria bacterium RIFCSPHIGHO2_01_FULL_42_15.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1801742 {ECO:0000313|EMBL:OGI68287.1, ECO:0000313|Proteomes:UP000178235};
RN [1] {ECO:0000313|EMBL:OGI68287.1, ECO:0000313|Proteomes:UP000178235}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI68287.1}.
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DR EMBL; MFTS01000004; OGI68287.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6VF70; -.
DR Proteomes; UP000178235; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 595..676
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 29..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 76037 MW; 5E09FC8DDADDD010 CRC64;
MKNSKNNPSN RLEGIISITS KGTGYVAVGD LPAGRQGKNN NQDPEIDSKH LNTALHGDTV
EIVLHPKGKN RQTAEVSKII SRAKIGFAGV LELQGSMFFL KPDDTKMYTD ILIPENMLNG
AKAGQKVFAE IVSWTDPRKA PEGKVTKILG TPGDNDAEMH AIAIEKGFDS KLPEKVYREA
EEIKKGGIKE SDYAGRRDFR KILTFTIDPA DAKDFDDAIS FRRITSPQPS PGEERGKAPS
PFQGKAGDEV FEIGIHIADV SHYVKVGSAL DKEARERGTS VYLVDRTIPM LPEELSNDLC
SLVPNKDRLT MSAVFVIDKN AKVKSEWYGR TVIHSQKRFT YEEAEESLGH RPATGEAIKK
TGDPLHKELA ILNNLAKLLT TERFKNGAIS LEQEEVKFVL DPTGVPIKVI TKERGDSNRL
VEEFMLLANK KVAEILSKNL SLYRIHDLPS KEKMADLAYF LRSLGHKISL VNGIISSHEI
NKLLKKLEGK NEEGTVNRAV IRSMAKAIYS TKNIGHYGLA FEYYTHFTSP IRRYPDIIVH
RLLTDYLSGK KVSKEHLLEY EKTARISSEQ EKRASDAERA SIKYKQVEYM SKRTGESFEG
VISGITEWGI YVEETETKCE GLVRVRDMKD DFYIFNEKKL ELVGQKRKKK YKLGDKVKIK
VKGVDLERKT IDYILL
//
