ID A0A1F6VP54_9BACT Unreviewed; 237 AA.
AC A0A1F6VP54;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN ORFNames=A3B84_00660 {ECO:0000313|EMBL:OGI71359.1};
OS Candidatus Nomurabacteria bacterium RIFCSPHIGHO2_02_FULL_35_13.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1801748 {ECO:0000313|EMBL:OGI71359.1, ECO:0000313|Proteomes:UP000177112};
RN [1] {ECO:0000313|EMBL:OGI71359.1, ECO:0000313|Proteomes:UP000177112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC {ECO:0000256|RuleBase:RU362028}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|RuleBase:RU362028};
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI71359.1}.
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DR EMBL; MFTY01000015; OGI71359.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6VP54; -.
DR STRING; 1801748.A3B84_00660; -.
DR Proteomes; UP000177112; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF44; PSEUDOU_SYNTH_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362028}.
FT DOMAIN 12..180
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT ACT_SITE 69
FT /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ SEQUENCE 237 AA; 27283 MW; 51EF3BAF8BCA2F53 CRC64;
MTIKILYEDS DILAIEKPSG VSMHSDGRSK EKTISDWFLK NYPKTKNVGE SIFTNGKEIK
KSGIVHRLDK ETSGVMLLAK NEKAHEFLKN QFKERIVKKT YHAIVSGWVK NDHGTINKPI
GRSPKDFRRH LAGRGVRGKL REAITEYKVL KRFKISTNKF TYLEIHPKTG RTHQIRVHMK
FINHPVACDS LYNPGKPCPK GLKRLGLHAK SIEFKNLKEK TIKIESPLPR EFEKVVK
//