ID A0A1F6XEY0_9BACT Unreviewed; 258 AA.
AC A0A1F6XEY0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=A2933_01010 {ECO:0000313|EMBL:OGI92558.1};
OS Candidatus Nomurabacteria bacterium RIFCSPLOWO2_01_FULL_46_18.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1801783 {ECO:0000313|EMBL:OGI92558.1, ECO:0000313|Proteomes:UP000179381};
RN [1] {ECO:0000313|EMBL:OGI92558.1, ECO:0000313|Proteomes:UP000179381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI92558.1}.
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DR EMBL; MFVH01000007; OGI92558.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6XEY0; -.
DR Proteomes; UP000179381; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..258
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 258 AA; 29861 MW; 1B5EB7B57108227A CRC64;
MPIKSLTHEL LWFMRGDTNL KYLADNNVHL WDEWPYKAYL IRNNIKIPII RSEEWNAGMK
EYTEKIKSDE KFAKEYGDLG PIYGYQWRSW PAPNGKHIDQ LAKVIEQIKK NPDSRRLIVS
AWNVADIDEM AKAGLPPCHC LFQFYVANGK LSCQLYQRSC DTFLGIPLNI ASYSLLTMII
AQICGLELGE FVWTGGDVHL YSNHMDQARL QLSRRGDIRS LPKMKINPEK KKLEDFVIED
FELVDYNPHE GIKAPIAV
//
