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Database: UniProt
Entry: A0A1F7AUQ0_9BACT
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ID   A0A1F7AUQ0_9BACT        Unreviewed;       566 AA.
AC   A0A1F7AUQ0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=A2344_00180 {ECO:0000313|EMBL:OGJ48961.1};
OS   Candidatus Peregrinibacteria bacterium RIFOXYB12_FULL_41_12.
OC   Bacteria; Candidatus Peregrinibacteria.
OX   NCBI_TaxID=1801905 {ECO:0000313|EMBL:OGJ48961.1, ECO:0000313|Proteomes:UP000177302};
RN   [1] {ECO:0000313|EMBL:OGJ48961.1, ECO:0000313|Proteomes:UP000177302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGJ48961.1}.
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DR   EMBL; MFXI01000031; OGJ48961.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000177302; Unassembled WGS sequence.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   InterPro; IPR003099; Prephen_DH.
DR   Pfam; PF02153; PDH; 1.
DR   Pfam; PF00800; PDT; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000177302};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        7    269       Prephenate/arogenate dehydrogenase.
FT                                {ECO:0000259|PROSITE:PS51176}.
FT   DOMAIN      295    477       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      492    566       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   566 AA;  63730 MW;  0A185544C8AD3487 CRC64;
     MQKNNKPIIG IIGGKGNMGS VFADFFEGLG YKVLISDLKT NLKSAELVKK SNVVIVSVPI
     DKTIEVIKSI VPLLKKDQLL MDFTSLKEAP IAEMLKSKAS VIGLHPMFGN STFGPGQKIL
     VSPARSGKWM PWIKEVFEEK GEFILKTISP QDHDKLMSLE QVLVHFTDFA FCKALQERGV
     KVEDILYYAT PAAGLKMEMA ARLLSQDAGL YANIQINNKY SEDVIRTLLK TSAELFYLVK
     NKDLKGFMNY FNTAGEFLGD YRTKAQSESD WLIFQWLEKF NQTDHIKKGK YSKSDIGVLG
     PKNSYSHQAS EKIINSIKLK NDICFMSSID EIFMAVEKGE IFAGIVPLEN LITGTIRETM
     DNLFKKNIKI VHEYKMDIHH CLAVLPSVGA KKGIKSIYSH QQGLYQCSDF IKKHYKNAEL
     INKPSTSWSF DYIKKLHLND AAVIASEKTA IENGFEVIAK NIENDKNNKT TFVLIGRQNM
     KLKTKKQNKV SISFHFSRDN AGSLYGVLGD FAKAKINLTR LESRPAEHRL GEYIFFVDFD
     GTVAAAEPVL RAIKKKVAKL KILGEY
//
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