ID A0A1F7AVV1_9BACT Unreviewed; 390 AA.
AC A0A1F7AVV1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase {ECO:0000256|RuleBase:RU004395};
DE EC=4.6.1.12 {ECO:0000256|RuleBase:RU004395};
GN ORFNames=A2335_02325 {ECO:0000313|EMBL:OGJ49512.1};
OS Candidatus Peregrinibacteria bacterium RIFOXYB2_FULL_32_7.
OC Bacteria; Candidatus Peregrinibacteria.
OX NCBI_TaxID=1801906 {ECO:0000313|EMBL:OGJ49512.1, ECO:0000313|Proteomes:UP000177576};
RN [1] {ECO:0000313|EMBL:OGJ49512.1, ECO:0000313|Proteomes:UP000177576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-
CC erythritol 2,4-cyclic diphosphate + CMP; Xref=Rhea:RHEA:23864,
CC ChEBI:CHEBI:57919, ChEBI:CHEBI:58483, ChEBI:CHEBI:60377; EC=4.6.1.12;
CC Evidence={ECO:0000256|RuleBase:RU004395};
CC -!- SIMILARITY: Belongs to the IspF family.
CC {ECO:0000256|RuleBase:RU004395}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGJ49512.1}.
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DR EMBL; MFXJ01000098; OGJ49512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7AVV1; -.
DR STRING; 1801906.A2335_02325; -.
DR Proteomes; UP000177576; Unassembled WGS sequence.
DR GO; GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0070567; F:cytidylyltransferase activity; IEA:InterPro.
DR GO; GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02516; CDP-ME_synthetase; 1.
DR Gene3D; 3.30.1330.50; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; 1.
DR InterPro; IPR034683; IspD/TarI.
DR InterPro; IPR003526; MECDP_synthase.
DR InterPro; IPR036571; MECDP_synthase_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR00151; ispF; 1.
DR PANTHER; PTHR32125; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR32125:SF4; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01128; IspD; 1.
DR Pfam; PF02542; YgbB; 1.
DR SUPFAM; SSF69765; IpsF-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|RuleBase:RU004395};
KW Lyase {ECO:0000256|RuleBase:RU004395}.
FT DOMAIN 238..387
FT /note="2-C-methyl-D-erythritol 2,4-cyclodiphosphate
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02542"
SQ SEQUENCE 390 AA; 44233 MW; 136DC67266206204 CRC64;
MLYIIFLAAG DSKRFGKNSK IFADLNDEPI FLHSLKTFLK LKEEKKIIVV AKPKDKIKIK
NILNQNQIST EIITGGKTRQ ESVFKGFEWI NNKIHKPHIK NHLIIHNAAN PLVTLKEIQN
CLKTAKKYEC SAVGNKIHDT IRYTNRQQTS TLVRKNLYLM QTPQIIRFDI YKKAYEFAKK
IGFEGTDDIN LVENYLNEMK NKIQIKIIPA SRQNFKITTK EDLKLANKIL NKNSNYQKIG
IGEDSHDFDK KGYLTLGGLI LKNYFKLKAN SDGDVMIHAL CNALSSALGG KSLGSFADKL
CLKEKITNSK KFLEPLLINL KKKKEKIQSL SFSLECEIPK IDEISDNLKK SIAKILKISK
SKIGITATTG NKTTTLRGVK CSCIILITQN
//
