ID A0A1F7HIK0_9BACT Unreviewed; 482 AA.
AC A0A1F7HIK0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN ORFNames=A3F29_02345 {ECO:0000313|EMBL:OGK30915.1};
OS Candidatus Roizmanbacteria bacterium RIFCSPHIGHO2_12_FULL_33_9.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1802045 {ECO:0000313|EMBL:OGK30915.1, ECO:0000313|Proteomes:UP000177199};
RN [1] {ECO:0000313|EMBL:OGK30915.1, ECO:0000313|Proteomes:UP000177199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGK30915.1}.
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DR EMBL; MFZV01000039; OGK30915.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7HIK0; -.
DR Proteomes; UP000177199; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 3..177
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 482 AA; 53344 MW; 79AB999B75C819FD CRC64;
MKNRPPIVAI LGHVDHGKTT LLDFIRKSKL AEKEHGKITQ SIGAYEIKTG IKGYNTDRIT
FIDTPGHEAF SKLRSRGANV ADFAILLIDA KDSVMPQTEE SISHIKNAGI PFIIVLNKID
LKDARPEKVK TDLLKYDVMV EDKGGKVPTV NISAKEGKGI SELLEAILLI SSEMNLKYDD
KTQPIAYIIE TKKDRRGNVV SSIIKQGELK VGDTVYSSGQ KTKIRSLFND MNKSVRSVLP
SSPFELLGFN ELPQVGSEIR TSDQKLTEKV ADTISQKRTL KIEELLEKNK GKKLNVILKA
DSKGSLEAIN DALAKKGNIE IVMQGIGTVQ KSDVFLATSS KSIILAFNID IESEAQDVAK
NEKIIIKNFN IIYELLDELE EVSDLMTQKD MIEKDLKGES VVLASFMIHD KLVYGVKVTK
GKINLGDNIQ IVRNNNLIAK TKLSSLQIRS KAVKEVKKGQ ESGIMIIPSV DIKVGDVLKY
SL
//
