ID A0A1F7I8Y8_9BACT Unreviewed; 614 AA.
AC A0A1F7I8Y8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A2954_01515 {ECO:0000313|EMBL:OGK39823.1};
OS Candidatus Roizmanbacteria bacterium RIFCSPLOWO2_01_FULL_37_12.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1802056 {ECO:0000313|EMBL:OGK39823.1, ECO:0000313|Proteomes:UP000177698};
RN [1] {ECO:0000313|EMBL:OGK39823.1, ECO:0000313|Proteomes:UP000177698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGK39823.1}.
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DR EMBL; MGAG01000036; OGK39823.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7I8Y8; -.
DR STRING; 1802056.A2954_01515; -.
DR Proteomes; UP000177698; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00141; NT_POLXc; 1.
DR CDD; cd07436; PHP_PolX; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.150.110; DNA polymerase beta, N-terminal domain-like; 1.
DR Gene3D; 3.30.210.10; DNA polymerase, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR002054; DNA-dir_DNA_pol_X.
DR InterPro; IPR010996; DNA_pol_b-like_N.
DR InterPro; IPR027421; DNA_pol_lamdba_lyase_dom_sf.
DR InterPro; IPR037160; DNA_Pol_thumb_sf.
DR InterPro; IPR002008; DNA_pol_X_beta-like.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR InterPro; IPR029398; PolB_thumb.
DR InterPro; IPR022311; PolX-like.
DR InterPro; IPR047967; PolX_PHP.
DR PANTHER; PTHR36928; PHOSPHATASE YCDX-RELATED; 1.
DR PANTHER; PTHR36928:SF1; PHOSPHATASE YCDX-RELATED; 1.
DR Pfam; PF14791; DNA_pol_B_thumb; 1.
DR Pfam; PF14716; HHH_8; 1.
DR Pfam; PF02811; PHP; 1.
DR PIRSF; PIRSF005047; UCP005047_YshC; 1.
DR PRINTS; PR00870; DNAPOLXBETA.
DR SMART; SM00481; POLIIIAc; 1.
DR SMART; SM00483; POLXc; 1.
DR SUPFAM; SSF47802; DNA polymerase beta, N-terminal domain-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..349
FT /note="DNA-directed DNA polymerase X"
FT /evidence="ECO:0000259|SMART:SM00483"
FT DOMAIN 373..459
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 614 AA; 70381 MW; 3A34D6357444C6C7 CRC64;
MKSDQNKFSN KEIAKILRNI AAVHLLKNEN RFKRVAYENA AETVEQSSRE LRDIWQDGKL
FDIPGIGKTI GSNLEEYFKT GKSKHFNSIL KKVPSTVFIL MNLPTIGPKK AYKLVKELKL
LIPKTVIEDL QNACKQNKVA ELESFGKKSQ EDILEAIKLF RKRSSKSERM PLPYAYELAK
ELSDYLKKIP GITRVDTLGS LRRMVATIGD IDISVQVESR KDHKVERLQK EIINYFVKFP
KTISIDSSGE NKASIIVSPN IRVDLRVQEE RSYGAMLQYF TGSKSHNIKL REYALKKGLS
LNEYGIKKVK SQKSKVKSIN QNSKILEFST EEKFYNFLGL QYIPPEIREG TNEIELSEKN
KVSKLVELKD IKGDLHIHSS YDLKPSHDLG ENSYSEILEK ADQLGYEYIG FTDHNPKTSG
LPEQEITEIM NLRYRVIKKL SNKVNEAKFF IGLEADIQPD GRLALPEKAI DLVDYLIVSV
HSAFNLDVKS MTQRVMKALS YPKVKILGHP TGRLLGKREG FELDWKAIFD FCRNKKIALE
INSWPERLDL PDSLVREALN QKVKFVINTD AHANLHLDGM IYGVSVARRG WCKKDDIINT
LDYSAFKRWL NNKS
//
