ID A0A1F7J6P0_9BACT Unreviewed; 1071 AA.
AC A0A1F7J6P0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A3B50_04780 {ECO:0000313|EMBL:OGK51277.1};
OS Candidatus Roizmanbacteria bacterium RIFCSPLOWO2_01_FULL_40_42.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1802066 {ECO:0000313|EMBL:OGK51277.1, ECO:0000313|Proteomes:UP000178558};
RN [1] {ECO:0000313|EMBL:OGK51277.1, ECO:0000313|Proteomes:UP000178558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGK51277.1}.
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DR EMBL; MGAQ01000002; OGK51277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7J6P0; -.
DR Proteomes; UP000178558; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1071 AA; 121549 MW; 86CE3D97E776AFB9 CRC64;
MSFVHLHNHT EFSLLDGMAR VEESIQKAKE LGMPALAITD HGALYGAFKF FLKAKEYGVK
PIIGVEAYKA KNSRFDKQIS IDRDQNHLIL LAKNLNGYQN LMKLVTQAHL EGFYYKPRID
FDLLEKYGEG LIALSGCLKG ELPQLIMENQ TTEADKVLKK YLQIFGKNFY IEIQRHPKMP
ELDSVNEQLI KLSRKHAVPL VATNDVHYIN KDDAYAQEIL LCIQTQRTIL ENNRPLSMYN
NPDFYFKSAS EMKGQFLDLP EAIDNTVKIA EECNLEIPYG NWILPRFETP KGETAAQYLK
ELVEKKAHRL KDSKGKEVQD RTKYELDIIT SKGYSTYFLI VQDFVNWAKE NHIMVGPGRG
SVAGSLVAYI LGITDINPLL YNVPFERFLN PERPTPPDID IDFADIRRDD VLHYVRQKYG
EDRVAQIITF GTMEARLVVR DVARALGWSY SQADRLAKMI PPGRQGFSMS IAQALEESSV
LKFAYQTEPE TKKLLDIAQK LEGLPRHAST HAAGIVISDK PLTEYVPLQK ENKEGKIITQ
YDMYCLDLNA VSSNQAIGLL KVDLLGLRNL TILEETLKYV EKTTGKKINI HEVPLDDKKA
YELVSEGKTI GVFQLESTGM RRLAKDLKPN KLSDIIAMVA LFRPGPMELI PIFLEGKSNP
QGVRYLHQDL KPILEETYGV LVYQEQVMEL ANKLAGYSMS EADNFRLAVG KKKKGLMKIE
KEKFIKGAIK NKYSKSLADK IFNFIEKFAA YGFNKPHSTS YALIAYWTAY MKANYPAEFM
TALLTAELQG IAGPMREIKM AQALEECRRM KIKVLPPDIN RSYESFRIEG NGVRFGLSAI
KNVGHAAIES IVEARNKGDF RGFKDFLLRV DLRKVNKRTV ESLIKTSAFS KFGNRATLLS
VYPKLVKEIG ELKVDKEKGQ SGLFDVAGRD EVLKDNFEEI KEFTEDEIFA MEKEVIGFLI
NKNPLEKFKE IVEKKATKKI GEISRDDLNQ KLVLVGIISG KKVIKTKKNN DEMAFVTLFD
ETGSVETVVF PSLYKKLLSV LAINQVLIFK GSITEKDDRI SMIMDVAMKL S
//