ID A0A1F7JKZ4_9BACT Unreviewed; 574 AA.
AC A0A1F7JKZ4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RCK N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51201};
GN ORFNames=A3J15_03530 {ECO:0000313|EMBL:OGK56255.1};
OS Candidatus Roizmanbacteria bacterium RIFCSPLOWO2_02_FULL_38_10.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1802074 {ECO:0000313|EMBL:OGK56255.1, ECO:0000313|Proteomes:UP000176376};
RN [1] {ECO:0000313|EMBL:OGK56255.1, ECO:0000313|Proteomes:UP000176376}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGK56255.1}.
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DR EMBL; MGAY01000043; OGK56255.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7JKZ4; -.
DR STRING; 1802074.A3J15_03530; -.
DR Proteomes; UP000176376; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF6; CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..543
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 574 AA; 64336 MW; C1BDFE83716276D9 CRC64;
MGALSLPVLL NTILFLLVSF IGGYLAVRYK LPAIVGYIIG GIILGFLLKE QFSSDFLSHF
AEIGIIFLLF TVGLEMNIAA LRRFGRLVIV GGLAQILLSA FFLILLSMAF RFSLVESLII
GFSFSLSSTV VVAKIIQDRG EENSLYGALA IGVLVFQDIV AIPLIIISSS LDGQVEGFAL
LKNIFLAIFR SGLVLIMMYF IGKRLVPYFF GKVAKRSREI LNLFTILFIF STVYVFSYLG
LSAGIAAFIA GVLLSQTLEH YHIFSQIRPI RDIFAILFFV FLGASVNLPM IIVSIPAILL
FTFFLITIKI AVTLGIYLFL HLHSRTSFSL AISLAQVGEF AFVILYQGLN LKIIAETNYH
FTLVAVLLSI ILTPILAQHR NTFYIYIKKW VKKLVPPLYH YVSHTLDREP PHIEALNIKH
HVIICGFGRV GRYIGRALSM AEVPFIAIDF NLYTVEKAKE QGINIIYGDP TNIDILDYAQ
AEAATCIVSA VPERFSQETI ILNAKKLNPK IIIFTRVDHE FDQRRMKDLG AEVVIQPEFE
AALSIIRKIL YDFNISKDDI IGKIKRLKIE HGME
//
