ID A0A1F7VA20_9BACT Unreviewed; 779 AA.
AC A0A1F7VA20;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE Flags: Fragment;
GN ORFNames=A3I40_01665 {ECO:0000313|EMBL:OGL87311.1};
OS Candidatus Uhrbacteria bacterium RIFCSPLOWO2_02_FULL_48_12.
OC Bacteria; Candidatus Uhrbacteria.
OX NCBI_TaxID=1802407 {ECO:0000313|EMBL:OGL87311.1, ECO:0000313|Proteomes:UP000178723};
RN [1] {ECO:0000313|EMBL:OGL87311.1, ECO:0000313|Proteomes:UP000178723}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGL87311.1}.
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DR EMBL; MGEP01000021; OGL87311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7VA20; -.
DR STRING; 1802407.A3I40_01665; -.
DR Proteomes; UP000178723; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..99
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 100..403
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OGL87311.1"
SQ SEQUENCE 779 AA; 89649 MW; 78872399B5F589BA CRC64;
DFGDLINYTL KLFCTRPDIL NFYRQQFKYI LVDEFQDTNW AQYEMVKLLA APLNNLTVVG
DDDQSIYRFR GASMSNILQF KKDYPAAQEV VLIANYRSSQ NILDLAYRFI QRNNPNRLEW
QMSEGRKQEG GGQSSSLSKS LKAATALEGI IEHLHGETID DELRLMAEKI LEFKSKDKEA
SWGDFAVLAR SNEQVNQADL AMGSLGLPHQ SVTAKGLYLK PVIVDVLAYL RLLDNYHESP
SLWRVLNFPF WKLRPRDLVE LSHFASKKSW SLFEALEKSA LIPNLHEETH RIFGTVLKWI
NEHTVFARDH RPSELLVKVL NEIGYTGYIE SKPEGQSRNE FSYLNQFHRR IKRWEETEAD
PRIRDFMPAI TYEIESGEVG DLSVDVEVGP DVVRVMTVHA AKGLEFKYVF VTGLVDRRFP
TTERRDPIEL PDALVKEILP QGDNNIHLEE ERRLFYVAMT RAKRGLWLAS AEDYGGSRKK
KLSQFLIELD IPLAGGKKAA ANVSGLPALV LGDLVDADII KDYLPEQFSF TQLKAYETCP
YQYRYAHVLK VPVWGRHTFS FGQSMHLTLE RFFTRLKEKK SARQGSLFAE GQPSAAAEPT
LEELLQIYES SWIDEWYESK DQAQEYFNLG RDILKEFFKK HEDAWPDTKF LEKGFNLKIG
SYTLKGKVDR VDARGDGVEI IDYKTGSVPK NEDVDKDQLF IYQLAAENIW QEKPVALTFY
YLGENKPISF LGTAHDLEAL KKKIISTIEE IRKSEFKAKP SPQTCRHCDF KKICPFSQA
//
