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Database: UniProt
Entry: A0A1F7VGW3_9BACT
LinkDB: A0A1F7VGW3_9BACT
Original site: A0A1F7VGW3_9BACT 
ID   A0A1F7VGW3_9BACT        Unreviewed;       452 AA.
AC   A0A1F7VGW3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   16-JAN-2019, entry version 21.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=A3I45_03885 {ECO:0000313|EMBL:OGL89733.1};
OS   Candidatus Uhrbacteria bacterium RIFCSPLOWO2_02_FULL_53_10.
OC   Bacteria; Candidatus Uhrbacteria.
OX   NCBI_TaxID=1802411 {ECO:0000313|EMBL:OGL89733.1};
RN   [1] {ECO:0000313|EMBL:OGL89733.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGL89733.1}.
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DR   EMBL; MGET01000025; OGL89733.1; -; Genomic_DNA.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124}.
FT   DOMAIN      311    412       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    258    258       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     153    153       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     261    261       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     325    325       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   452 AA;  48941 MW;  B1393FD2A06DDBC0 CRC64;
     MNIAVVGTGY VGLVTGACLA DRGHCVICID SNEKIIEGLI RGTVPIHEPG LEDVVLRTTA
     SDGLTFCISI REGISDAEVI FLCVGTPPKN DGSADLSHVF GAAEEIGRVL DHDAVVVSKS
     TVPVGTSHRI KSIIAKTYKG AFDVASNPEF LREGNAVSDF FRPDRLVIGT DGKRAQETMA
     LLYEVFDCEK VFTDIESAEM IKYASNAFLA TKISFINEMA QVCEAVGADV EDVARGMGLD
     SRIGPKFLRA GLGYGGSCFP KDVRALYQTA GLNGYQFQLL RSVIEVNNTI RWTFYQKIKS
     VLGGFQGKRI AVWGMAFKPD TDDIRESIAL EYIERMQDEG AQVVAYDPVA GARVAKARPK
     IMLAHSALEA AKDADAVVLV TEWDEFERVD LKALSKMMHT PVLFDGRNVF DVESMRAAGF
     VYHSIGRVPV ASSSASIPAP LVGIEIASLR SQ
//
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