ID A0A1F7W8Y8_9BACT Unreviewed; 693 AA.
AC A0A1F7W8Y8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=A2304_05150 {ECO:0000313|EMBL:OGL98848.1};
OS Candidatus Uhrbacteria bacterium RIFOXYB2_FULL_57_15.
OC Bacteria; Candidatus Uhrbacteria.
OX NCBI_TaxID=1802422 {ECO:0000313|EMBL:OGL98848.1, ECO:0000313|Proteomes:UP000176501};
RN [1] {ECO:0000313|EMBL:OGL98848.1, ECO:0000313|Proteomes:UP000176501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGL98848.1}.
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DR EMBL; MGFE01000014; OGL98848.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7W8Y8; -.
DR Proteomes; UP000176501; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43711:SF1; HISTIDINE KINASE 1; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 336..387
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 473..692
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 693 AA; 77339 MW; 8BE581685EE68B70 CRC64;
MEVEQGRNFR WLAKLVYITV IFFVTLAVCF SIWRIYQSTT EATVERRQAI VSLAAASTEL
RFEYLKDLGV SFATRVRFRE FISTNDWDGA IGILSDVTEN FPYIDRIFIT DPSGMLMADV
PALSDVRGKN FAFRDWYIGV SDGWKPYVSD VYQRTAEPRY NVVAISVPIV ADTGEILGIL
VLQIRADQLV NWMRSAVEGT NMVAYLVDPK GHPVGNPLVD PQESLLDFSD QPFVAAVLNN
ERGLGIYSGI NGGNESLVVY EPISLFGWGV VVSEEIDSAF ATRNEILSIA VLIFLIAVGI
VVFLVSLLYL MLMRLQRMSL ELDARVESRA RAFGEEHAKI QAIIESMIDG VIVSDLRGRV
VLANQEIRRL LGYVPSELQG KKIFSSLEMR DRTGKIIPES RRPMLQALHG KITRIPTVTD
ANFYVRKDGT LFPALVTCAP VLVDGKVAGA VSVLRDATKE YAVDRAKNEF VRLASHQLRT
PLTAILWYVQ NMIEGSVGRL SKPQTEHLKI IEYSTRRMIR LVNDLLRVSQ IDLSQIPSRI
HGMELQPVVG SVVEELFEVA SERNVSVTVS SPRSLPLVRA DELLVRQSLL ILVGNAIAFT
PAKGRIKIIL ERVTNDVRIS VRDTGIGIPK DEQGRVFQRF FRASNAQKYT GEGTGLGLFI
AKEIVNLSKG KIGFSSEEGR GSTFWISFPI VRS
//
