ID A0A1F7X2Y8_9BACT Unreviewed; 404 AA.
AC A0A1F7X2Y8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
GN ORFNames=A2159_00820 {ECO:0000313|EMBL:OGM09460.1};
OS Candidatus Woesebacteria bacterium RBG_13_34_9.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802477 {ECO:0000313|EMBL:OGM09460.1, ECO:0000313|Proteomes:UP000179219};
RN [1] {ECO:0000313|EMBL:OGM09460.1, ECO:0000313|Proteomes:UP000179219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM09460.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MGFP01000023; OGM09460.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7X2Y8; -.
DR Proteomes; UP000179219; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00533; HMG_CoA_R_NADP; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361219}.
SQ SEQUENCE 404 AA; 44204 MW; 1C6BAD79B29DF675 CRC64;
MIKKKQKAFE KIVKEKKFHS QFNNLCFEDQ MDIRRQALEK LTHTKLQYIN HPSFNIEHVS
TKNCENLIGK VEIPLGIAGP LKIHGNYAKG NFYIPLATTE GALIASVNRG CKAVDRSGGA
QVFIEKSGMT RAPLFRTKGL KQTKKFIAWI NTHLKEIAER VHKTDSHLTL LSITPFIVGR
NVFLRFVFDT QDAMGMNMVT IACNYIRNYI EKEMKVECVA LSGNVCTDKK PSWINKIEGR
GYSVHAEARI PKNIIREILK TDLEKIIEVH INKNLVGSSI SGSMGFNAHH VNIIAAIFAA
TGQDLAQVVE GSIGNTIFEK TGEDLYASVS IPDLPLGTVG GGTQLETQKE ALSILGVAGG
GNPPGSHAKK LAEIVVSATL AGEISLISSL AQGSLAHAHQ KLGR
//