ID A0A1F7X4A5_9BACT Unreviewed; 334 AA.
AC A0A1F7X4A5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
GN ORFNames=A2Y68_00710 {ECO:0000313|EMBL:OGM09934.1};
OS Candidatus Woesebacteria bacterium RBG_13_46_13.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802479 {ECO:0000313|EMBL:OGM09934.1, ECO:0000313|Proteomes:UP000176778};
RN [1] {ECO:0000313|EMBL:OGM09934.1, ECO:0000313|Proteomes:UP000176778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. GDP-mannose 4,6-dehydratase subfamily.
CC {ECO:0000256|ARBA:ARBA00009263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM09934.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MGFR01000002; OGM09934.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7X4A5; -.
DR STRING; 1802479.A2Y68_00710; -.
DR Proteomes; UP000176778; Unassembled WGS sequence.
DR GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR CDD; cd05260; GDP_MD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR006368; GDP_Man_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
FT DOMAIN 6..325
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 334 AA; 37458 MW; 5A5AC65F40BBA82A CRC64;
MAKKALITGI TGQDGSYLAE LLLKKGYEVS GIVRKSSHLR YANIELIQES LNLIQADLLD
PVSLREAIQI VKPDEIYNLA SQSVPRESFK QPIHTAEITG LGAHRVLDAA WDIVPKAKFY
QASSSEMFGW VKEIPQNEET PFNPANPYAA AKLYAHNIAK IYRESYKMFI SCGILFNHES
PKRWLGFVTQ KVAYAAACAK LGVKNSPYLN EEGEPIVKNG KVAMGNLDAK RDWGYAGDFV
IAMWLMLQQD KPDDFVVATG ETHTIKELCE KAYDYVGLNW KDHVEVDERF VRPTETGPLV
GDYAKAKKVL GWEPKVGFEK VIEMMVDANI ARLK
//
