ID A0A1F7XV16_9BACT Unreviewed; 826 AA.
AC A0A1F7XV16;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=A2685_02305 {ECO:0000313|EMBL:OGM18559.1};
OS Candidatus Woesebacteria bacterium RIFCSPHIGHO2_01_FULL_37_10.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802489 {ECO:0000313|EMBL:OGM18559.1, ECO:0000313|Proteomes:UP000178446};
RN [1] {ECO:0000313|EMBL:OGM18559.1, ECO:0000313|Proteomes:UP000178446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM18559.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MGGB01000045; OGM18559.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7XV16; -.
DR Proteomes; UP000178446; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 2.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 6.
DR Pfam; PF00521; DNA_topoisoIV; 2.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..456
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 826 AA; 91545 MW; 7D78A538942F3241 CRC64;
MGLTAGGSFS KSAKVVGEVL GKYHPHGDVA VYDSLVRMAQ EFSLRYPLIK GQGNFGSVDG
DSAAAMRYTE VKLSAISKYV LMDIEKETVN YFDNFDATLK EPEFLPALMP NLLLMGSEGI
AVGMATKIPP HNLREVVDAI IKTIDKGRVI LTNEKARQDE ADFVIKKINL IASGSENKFE
DSEVNSQVVS FESDITIEEV VSIIPGPDFP TGGAIYDAGS LLEVYAAGRG RINVRGIAEI
SEGAKGKSQI IISEIPYQVN KAELVIKIAD LVKDKKIVGI SDLRDESDKD GLRVVVDLKK
DAKPKSILNN LFKHTRLQTT FPANFVALVE GTPHTLNLKQ ILTEFVKHRQ KVITRRTIFE
LTEAKKRAHI LEGLIIALDN LDEVISTIRK SRTQDDAKQN LIKKFGLSEI QATAILDMQL
RRLAALEREK IEKEYKDIKK LIDELTAILK NPERVLKIII SELTELREKH GDERKTKIYK
AKIGEFSEED LIPKEDTLIT VTKTGYVKRV PRTTYRSQRR GGKGVVGMAT KEEDEIEHLV
SATTHDTILF FTNLGKVYGT RAWELPETSR QAKGQAIVNI INIEQDETIM SILPLGEDAK
HLLMTTSKGK VKKTSVSEFK NMRSSGIIAI RLDSDDSLVS VRETSGNDHV IIITKKGKSI
RFPESNTRHM GRATSGMMGI RLDKDDAVIA MEVFPAKEEI SKDKRKKIFR DILTISGRGL
GKRTPLRLFP VQKRAGKGVK AAVANDKTGN LTTAIMVDQK IEQIVITSTS GQVIKLPLKN
IPQMGRATQG VILMRFARKS DSVAAVATLE KNGDNESETE TEAEVS
//
