ID A0A1F7Y735_9BACT Unreviewed; 335 AA.
AC A0A1F7Y735;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN ORFNames=A2863_03925 {ECO:0000313|EMBL:OGM22448.1};
OS Candidatus Woesebacteria bacterium RIFCSPHIGHO2_01_FULL_38_9b.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802493 {ECO:0000313|EMBL:OGM22448.1, ECO:0000313|Proteomes:UP000178750};
RN [1] {ECO:0000313|EMBL:OGM22448.1, ECO:0000313|Proteomes:UP000178750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM22448.1}.
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DR EMBL; MGGF01000002; OGM22448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7Y735; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000178750; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725:SF47; CARNITINE ACETYL TRANSFERASE (AFU_ORTHOLOGUE AFUA_2G12530)-RELATED; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
FT DOMAIN 5..259
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 335 AA; 37510 MW; B413D52805A24D00 CRC64;
MSKKILVTGG GGYIGSVATY LLLQKGYEVV VIDNFSTGFK DPLKLFKSKF KSKFRYYGAD
LKKPLESIFK IEKNPDAVLH YAAHCMVDES MVYPQKYFSN NVCGSQNLLS TAISFNVRNF
IFSSTCAVYG EAEYVPVDEK HPTNPANPYG ASKRIVEEII KWYGELQHIN YVILRYFNVC
GASDDGVIGD SKKPSVLLVQ NAVKGALGIE PFHLTCPDVN TPDGTPIRDY INVVDLNEAH
IKALEHLFEK GKNEIINLGT GNGNSVLEIV NTVQNITDTK FDLKKAEARK GEYAEMVADI
RKAKNVLGWE PERNIEDSVN SLIKWYKKHP HGWDS
//