ID A0A1F7Z3N7_9BACT Unreviewed; 384 AA.
AC A0A1F7Z3N7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Cystathionine gamma-synthase {ECO:0000313|EMBL:OGM34286.1};
GN ORFNames=A3D01_00760 {ECO:0000313|EMBL:OGM34286.1};
OS Candidatus Woesebacteria bacterium RIFCSPHIGHO2_02_FULL_39_13.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802505 {ECO:0000313|EMBL:OGM34286.1, ECO:0000313|Proteomes:UP000177169};
RN [1] {ECO:0000313|EMBL:OGM34286.1, ECO:0000313|Proteomes:UP000177169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM34286.1}.
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DR EMBL; MGGR01000007; OGM34286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7Z3N7; -.
DR STRING; 1802505.A3D01_00760; -.
DR Proteomes; UP000177169; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2}.
FT MOD_RES 201
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 384 AA; 42064 MW; 977548EE77C740E1 CRC64;
MKYNTKIIQE GEKPNLKEGA YGDVSIPIHL SSTFARKEVE TPTGGYEYSR SGNPTRSALE
KKLAALELAD FGLAFSSGLA ATTTLLLSLT KSGDRVLASD DLYGGTKRLF NRVFDKQYSV
KFSYVDTSNI SGLEKAIKSD TKLIWLETPT NPLLKISDIK AIAKIAKKNN ILLVVDNTFL
SPYFQKPLTL GADIVLHSTT KYINGHCDSV GGAIMLSESN VFEKLKFNQN AVGAILSPFD
SFLTIRGIKT LALRMERHQE NALRVANFLS THPKVLKVYY PGLPTHPGYD IAKKQMTGFG
GMISFEIRGG ISTAKRFLSN LKLFALAESL GGVESLIEHP AKMTHASLSK QEREAVGITD
GLIRVSVGIE DARDLVKDLK QALK
//
