ID A0A1F7ZV18_9EURO Unreviewed; 1050 AA.
AC A0A1F7ZV18;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Na+/H+ antiporter Nha1 {ECO:0000313|EMBL:OGM43301.1};
GN ORFNames=ABOM_008673 {ECO:0000313|EMBL:OGM43301.1};
OS Aspergillus bombycis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=109264 {ECO:0000313|EMBL:OGM43301.1, ECO:0000313|Proteomes:UP000179179};
RN [1] {ECO:0000313|EMBL:OGM43301.1, ECO:0000313|Proteomes:UP000179179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 26010 {ECO:0000313|Proteomes:UP000179179};
RX PubMed=27664179;
RA Moore G.G., Mack B.M., Beltz S.B., Gilbert M.K.;
RT "Draft genome sequence of an aflatoxigenic Aspergillus species, A.
RT bombycis.";
RL Genome Biol. Evol. 0:0-0(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM43301.1}.
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DR EMBL; LYCR01000073; OGM43301.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F7ZV18; -.
DR STRING; 109264.A0A1F7ZV18; -.
DR OrthoDB; 1607026at2759; -.
DR Proteomes; UP000179179; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000179179};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..435
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 460..984
FT /note="Alkali metal cation/H+ antiporter Nha1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08619"
FT REGION 474..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..977
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 116179 MW; BE7C78BA41CB49D1 CRC64;
MAWDHLDIDK PHLAYMILGG FTGLFMLCSL FVKEKLYIGE ATVATLCGII FGPHAANLFN
PHEWGNIDKI TLECSRIVLV VQCFAVGVEL PKSYMNRHWK SVFLLLVPVM TWGWLITSLF
IWWMVPPLSW LESLVCAACV TATDPVLASS VVGKGKFAKR VPKHLRDLLS AESGCNDGMA
FPFIYLSFYI LRYRPDAGKV SLNWFCVTIL YECIFGAVYG FLIGYFARHA IKFAERKQLI
DRESFLVFYF VLAVFCAGSG SLLGMDDLLI GFAAGVGFSN DGWFTEKTEE SHVSNVIDLL
LNLAYFVYFG SIIPWEMYNA PELGLVPWRL VVIAILVIFF RRIPIMLILK PIIPDVKTWR
EALFAGHFGP IGVGAIFAAI LARAELETDS TQPLTEAELP KAGMADYYIV QLIWPITTFM
VISSILVHGS SIAVFTLGKR INTLTITLSY TTANDEGPSW MNRLPRVQSI AKGSMSFRKP
DDTDASSNEQ EYPPGTLPPI GVPGNFLRRV RDEDTESPTG RTSSRRPRRR RRHASGAGGP
ISQSAIAPQR PVESEDAEEE EVRDKIERES SPPSKERDQF GREPIVEAYL EGHHMIIEDE
EGNVLKTEDV SHISPEEQQR HIEAQRDRLL QEKSGEFAKS RSQPHARSEG EEVKEAIEEK
TGHPLEKVRK RFGQWIGLGK GRAQEADDQE VEEPPETKQQ AAAATADKKP KGKSRSAHAY
QFGNTIIVED EDGEVIKKYS IPSTDKPETG APVRRGLTRM GTWFGMDGEG EPSQAEKKTA
DDDWLADDGL RFTVADDDSI GKKGVSHKGR RMNKHEFVQQ LRNLGPRARR DLVEETDAPQ
RVKEVARDEA RGVERQESLA GDSARDTQHQ KATPARPASV SSSESSNGSD IGVPGDNIAA
SLARFTRGTA AEERRSTLDP STGPRSRRDS EDDGTERVPP AQLREAAGLS RPPQQDDDDA
GETPAERRRR LAALGELNSD DSDESDAVVE SDSEDNTGFR RVGSKVQFVE GTKASDSGTG
SNSNQGNGSS SSSSAHQRSI SWGGEKGREA
//
