ID A0A1F8A1J1_9EURO Unreviewed; 509 AA.
AC A0A1F8A1J1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Nuclear membrane fusion protein Kar5 {ECO:0000313|EMBL:OGM45195.1};
GN ORFNames=ABOM_005843 {ECO:0000313|EMBL:OGM45195.1};
OS Aspergillus bombycis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=109264 {ECO:0000313|EMBL:OGM45195.1, ECO:0000313|Proteomes:UP000179179};
RN [1] {ECO:0000313|EMBL:OGM45195.1, ECO:0000313|Proteomes:UP000179179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 26010 {ECO:0000313|Proteomes:UP000179179};
RX PubMed=27664179;
RA Moore G.G., Mack B.M., Beltz S.B., Gilbert M.K.;
RT "Draft genome sequence of an aflatoxigenic Aspergillus species, A.
RT bombycis.";
RL Genome Biol. Evol. 0:0-0(2016).
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM45195.1}.
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DR EMBL; LYCR01000045; OGM45195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8A1J1; -.
DR STRING; 109264.A0A1F8A1J1; -.
DR OrthoDB; 1940841at2759; -.
DR Proteomes; UP000179179; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368082};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000179179};
KW Signal {ECO:0000256|RuleBase:RU368082, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368082}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..509
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013085453"
FT TRANSMEM 474..501
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
SQ SEQUENCE 509 AA; 56963 MW; 3852346B0B23A7F6 CRC64;
MLLLFSLLFS ALCSTEDSAS DLLIHKNNSF EEVDLASFII SKNIQHDVIF KEAVQLLESM
RSSPSCNRIA ASRLVTSCQS VREKTHNVDS ETYRVLEHTR SLYAARLAIC ELEGAGTHIP
NACLPVTIPP PQKKGIFGFS IKSGSPVNGV DPIPVQLLES CLKSLESRPQ WWTSYSNSRQ
NAFVICQAAR IENEKEELLD LHRSLVQGSN KLNQGLQEAL RAAAAEFSQH RAFANEVANM
NARLVHDMEE TRSHFKTMIE KVFYKIEARA VSALNTITSV LGKAQAEATA LDKNIQNVSS
EVSKLQYTFQ DLLDEMLSAN EQITLAHQQN AVSHNELAVN LRSKLEYILQ DDVARLLHNL
EAFDSSLEWL SGRFGLLSEQ EMSISERLRS FDITLKEFQL RAENLHKAQL QQAEAVEFQS
KLQEKLQTSV QISQALLDKA AATTANLQAM IDETSARYKD SPVLRPLFST YSSWTFYGLL
LSLIASHNVK VALALLIISA FQFMATRIL
//
