ID A0A1F8A1P3_9EURO Unreviewed; 1111 AA.
AC A0A1F8A1P3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=ABOM_006268 {ECO:0000313|EMBL:OGM45634.1};
OS Aspergillus bombycis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=109264 {ECO:0000313|EMBL:OGM45634.1, ECO:0000313|Proteomes:UP000179179};
RN [1] {ECO:0000313|EMBL:OGM45634.1, ECO:0000313|Proteomes:UP000179179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 26010 {ECO:0000313|Proteomes:UP000179179};
RX PubMed=27664179;
RA Moore G.G., Mack B.M., Beltz S.B., Gilbert M.K.;
RT "Draft genome sequence of an aflatoxigenic Aspergillus species, A.
RT bombycis.";
RL Genome Biol. Evol. 0:0-0(2016).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA
CC mismatches thereby initiating DNA repair. MSH3 provides substrate-
CC binding and substrate specificity to the complex. When bound, the MutS
CC beta heterodimer bends the DNA helix and shields approximately 20 base
CC pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to
CC 13 nucleotides in size, but can also repair base-base and single
CC insertion-deletion mismatches that occur during replication. After
CC mismatch binding, forms a ternary complex with the MutL alpha
CC heterodimer, which is thought to be responsible for directing the
CC downstream MMR events, including strand discrimination, excision, and
CC resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch
CC repair functions. {ECO:0000256|ARBA:ARBA00025373}.
CC -!- SUBUNIT: Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a
CC ternary complex with MutL alpha (MLH1-PMS1).
CC {ECO:0000256|ARBA:ARBA00025902}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM45634.1}.
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DR EMBL; LYCR01000040; OGM45634.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8A1P3; -.
DR STRING; 109264.A0A1F8A1P3; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000179179; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000179179}.
FT DOMAIN 957..973
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1111 AA; 123253 MW; 3FA6320BD15965C7 CRC64;
MPLSSQPSSS PNLKRKQPTI SSFFTKKPQL SQESTSNDAF KEYERDQEGQ EVTKQEKASR
GNCSTRSNSV DDEDDVVAPA PKRARINGSY SQNTTESPKE THVERPRLSD NIPKTELSKF
ASSPATEGET KERTKEREKL HQKFVQRLGG PDCLIGIGRN TATEAVPEEA GEGDEGDEPS
PPPAAKGKAA TKKGGHKLTP MEKQIIDIKR KHMDTVLVVE VGYKFRFFGE DARTAAKELN
IVCIPGKFRF DEHPSEAHLD RFASASIPVH RLHVHVKRLV SAGHKVGVVR QMETAALKAA
GDNRNAPFGR KLTNLYTKGT YIDDMEGLEG STASISAAGT TMATGYMLCI TETNAKGWGN
DEKVHVGIVA VQPATGDIVY DEFEDGFMRS EIETRLLHLA PCEVLIVGDL SRATEKLVQH
LSGNKTNAFG DEIRVEKFPK AKTAAAESHS HVSSFYAERM KNANTTDDAQ ASSLLQKVLN
LSEQVTICLS SMIKHMSEYG LEHVFQLTKY FQHFSSRSHM LLNANTLNSL EIYHNQTDHS
TKGSLFWTLD RTQTRFGQRM LRKWVGRPLL DKSSLEERVD AVEELKNPER IALVERLKGL
LGRIKTDLEK SLIRVYYGKC TRPELLTLLQ TLQMIAQEFA GVQSPADTGF SSPLISKAVA
SLPTILEDVV HFLDKINMHA AKNDDKYEFF RESEETDEIT EHKLGIGAVE HDLEEHRSTV
GECLGKKKVE YVTVAGIEYL IAVENKSPSI KKVPASWVKI SGTKAVSRFH TPEVIRLLRQ
RDQHKEALAA GCDKAYASFL GEISASYQSF RDSVQSLATL DCLISLATIA NQPGYVKPEY
TDHTCIHVDQ GRHPMVEQLL LDSYVPNDID LDSDKTRALL VTGPNMGGKS SYVRQVALIA
IMGQIGSYVP AQSAKLGMLD AVFTRMGAFD NMLAGESTFM VELSETADIL KQATPRSLVI
LDELGRGTST HDGVAIAQAV LDYMIRSIRS LTLFITHYQH LSSMTHSFPD HELRNVHMRF
TESGLTEEEI TFLYEVGEGV AHRSYGLNVA RLANLPAPLI ELAKQKSAEL EQKIRRRRLA
GLVRTFGDVL SDPAKADETL IEQLISSAEQ L
//
