ID A0A1F8A752_9EURO Unreviewed; 5190 AA.
AC A0A1F8A752;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Nonribosomal peptide synthase Pes1 {ECO:0000313|EMBL:OGM47600.1};
GN ORFNames=ABOM_004233 {ECO:0000313|EMBL:OGM47600.1};
OS Aspergillus bombycis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=109264 {ECO:0000313|EMBL:OGM47600.1, ECO:0000313|Proteomes:UP000179179};
RN [1] {ECO:0000313|EMBL:OGM47600.1, ECO:0000313|Proteomes:UP000179179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 26010 {ECO:0000313|Proteomes:UP000179179};
RX PubMed=27664179;
RA Moore G.G., Mack B.M., Beltz S.B., Gilbert M.K.;
RT "Draft genome sequence of an aflatoxigenic Aspergillus species, A.
RT bombycis.";
RL Genome Biol. Evol. 0:0-0(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM47600.1}.
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DR EMBL; LYCR01000022; OGM47600.1; -; Genomic_DNA.
DR STRING; 109264.A0A1F8A752; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000179179; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 3.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 13.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000179179}.
FT DOMAIN 782..858
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2321..2397
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3418..3494
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4470..4546
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5190 AA; 577990 MW; C1539F4459BAA2D7 CRC64;
MAHSTQCFLP KFGSLSEGPK QPMSMRTRTS SSETTQLISA WQEGQLDALL QTTWALVLYR
YTGSADICFG CQHLTAHDYA THSSDSATIR TCRLSVSEDD SIRGLLEKAK GQIDLADSAE
KCGTLSGVTR NFRLYNTMMM IQNCRETTTT STDTPVAVIA LPNECHLRLH VKVLYEDIGI
FMEWWNNDIS TEQIRSMSSY LQQMLTRVLM ADDTVVSKLS GISESDWARI CKFNAETLEA
HDRCIHETIH EQTVLQPESE AVCAWDGSLT YSKLDLLASQ LAYHLQAQGV GPEVRVALCF
DKSKWNIVAL LAVLKAGGAF VPLDPTHPAP RLQSLVRSVQ ARIMLCSRNH AQNLRAVVEH
LIPLDSDTWE ELSIPCGDVS LSTEVKGSNA AYVIFTSGST GEPKGTLMEH KAYVSSAMAH
APRLRVFAYS RLLQFAAHTF DASLVEILTS LLVGACICVP SEEARLNNIT KVINDMRVNH
ATLTPSFIDF VNISDVPNLE TLVLAGEAMS QSHLEIWSKI NLVNGFGPTE TAVTAAVNSK
VTRSSDSRDI GLPTGVHCWI VDSDDHNQLV PVGCVGEMLA EGPSLARGYV NNQQKTDEVF
IYDPSWAKRQ GGGSGRRFYK TGDLVRYNSE AGSLTYIGRK DTQVKFHGQR IELGEIEDNL
NTDSNIRHCL VFLPKSGFSE GRIVAVLSLP IFDGISDSDP VPLRLLEDSK KNSTISQIRD
RLSARLPAYM IPTVWLCVET LPMLVSGKLD RKATANWVGN LENDPNIQLT KLDPILSESS
TQSENATEER LASIWSRVLN IPRTHISLDE SFLGQGGDSI AGLTCVGFCT KQGIGITVQD
ILRSKSIRDL ATRAKEIQQP ASYEETIEKP FGLSPIQKLH FMVRQEGQGH FNQSVLTRLN
QQVDEYDLRR SIETLISRHS MLRSRLADLG TDGLQQRITE DVAGSYRWRM HDVNRQDQIE
HAIADSQASI NVFTGPVLAV DMFNGNGKDY VLSLVAHHLV VDIVSWRIIL EDLEDLLLNP
DEAKSQTGSL PFQTWCQMQA DKCQELNTTL DDLPPPDFAY WGMEKCPITY GDVDCETFEV
DAESTRTLLM DCHQSLQTEP IDVFLASLLH SFLQTFSDRS LPVIYNEGHG REVWDSGIDI
SRTVGWFTIL HPITLHQIAE DDPVKTLIRV KDLRRRVMDN GRQDFARRLV GDAKDRGHPS
PMEISFNYVG QHRDLQRQDG LFQLMNQMAG EAGRGGGAAD FGEKTPRFAL FEISAMGVQG
RLRFTFSFNR YMKHQQSIRH WISNCHDLLK HLGSKLQSLA PKPTLSSFPM LSLTYEELET
IFSDRLPNVG IKSFEQVEDI YPCSRMQQGI LLSRSRDEGF YSVHDTFEVK SSEIEPDVNQ
LVLAWQQVVM HHPMLRTIFV DKLTSRELFC QVVLKTIDSQ PSIIRCVDES EVLAAFDEQD
PMTYVGYQPP HRFTICQTAS GKLFCRLEIN HVSMDGSSIS IIARDLQLAY AGKLETHRRP
MFKNFLHYLR EQDDSTGYWC SYLSDCRPCH FPVLNDGIIS EKKLRSVRLN VNFYSELLEA
CEKSGVTLSA AISTAWGLTL GQFCGSSDVC FSYLASLRDM PVEDIESVVG PVITLLACRM
KIPGNGLLED ILHRVQNDYM EQLSHRNTSL IDIQHALKLS DTTLFNTGVS YRKLPPNKAT
AEEVQLVEVG SIYDPAEFPV YVNVEVAEDD ARIDLNYWTT ALSVGQAENV ASVFLKALEN
IAQYQDTKAS TISDIDFLSE QACTQLCEWN AKLPDRPEKC AHEVIQQQAL YLPLSTPAIC
SWDANLTYSD VEHLSTRLAQ YLIGLGVGSE TFVTLFFEKS AWYVIAQVAV LKAGGAFVAL
DPSHPEARLR GLVEDVGAYV MLCSVKHTEK ASRLCDIVFG VCEATIDGLV IPATVMPAAT
PSIHTAAYAI FTSGTTGKPK VSVIEHISLG IAASTFPEIF RVGPGARVLQ FSNYIFDVHV
LETVITLMAG GCICIPSEEE RLNDLSGAIN RMGATMCTMT PSTTNTLNPE SVPTLGTVVT
GGEIMTKSHV DRWADRRVIN AYGPSEATVA STASVKADGG RRLTEDYNSI GTAFAGRSWI
VDPDNYHRLL PIGAIGELVL EGCNVGRGYL NNVEKTREVF ITDARWTEHS GLKKIFKNKE
RMYRTGDLVR YNADGSLCFI SRKDTQIKLN GQRIELGEVE QQCVGYLPAN TQVAVEVITP
EAKTVAKCLA VFFATGDHEE DESGLLLSTS ETTVDIVKKL HSSLKESLPV VMIPKLFFPV
RCLPIAATGK LDRKGLRAMV EPLPKEKLMQ YTTFNDGSRQ IAEGGAEGKL RALWEEALGL
APGSVGTDDS FFGIGGDSLS AMKLVSAADF QGVALTVADI YANPILADMA KICEHSEASA
DTVTVEPFSL LPSSVCKEAI QEVTDQCHIP EGSITDMYPC SPVQEGLITL STKQQGAYIA
RPIFKLTDEV NLEQFRAAWQ QTVDELDILR TRIVHTDSTG FLQVVLDKET ISWTAATTID
EIMDETPELP NQSGGSLTAY AIVQPRDSSS RYFVWTIHHA LYDGWSVSLI LKRVEELYKS
PSTTGSTLPY KLFISHLQDK DMSESDNFWR LQLADISCSP FPQSKASMSD AVRVGNRYHS
SVEIGRTPEI KDLTLPELIR AAWAIVISAH TSSSDVCFGE TLMGRNISLR GITEVAGPVL
TTVPTRVQVD SELLVTQFLQ NIRKLTTAMI PHQHSGLQRI RKLNDNTYLA CDFQNLLVIQ
TEEGTMNGDL WVPENNQTGS DFFTHPLTVE CKISGSKLVL TVHHDEIILD SWQTERLTNQ
FTHVIQQLLT FSEEDIRKVG DLVVASPQDK QEIISWNQRH PTRVDRCVHD IIREKGAAQP
EAPAVCAWDG QLSYREMYGY ASSFAAYLNS RGVGPETLVP ICLDKSVWAI VTILGILIAG
GAFVPLDPAH PTSRHKEILE DIEARVILCS PQYRNRYAGS VKTIVPVSQE TIRAYSALTR
KTPSPNCATP SNMAYAIFTS GSTGRPKGII IDHRALASSA TAFSPIVHLN ENSRAFQFAS
LTFDAAVMEV LATLMHGGCI CIPSEDERLN DVAGAIRRMD VSWAFLTPSI ASIIEPSTVP
SLKVLACGGE KLSREVVLKW AHRVKLINGY GPTETTIFAV LNDVTPGTEP ACIGYGIPST
LTWVVDPENH NRLSPLGAIG ELALEGAALA REYLKSPEKT ADAFVTEPTW IKDFPSSLPS
PRRIYKTGDL VRYNPDGSIE YISRKDHQVK IHGLRMELGE IEHRLCEDRR VRHAVVILPK
SGLIQKRLVA ILSLESLNSG SGLNSDAACE LISQDQMDVV YSELEEIQKG LESQLPIYMV
PQTWAVIKKL PMLVSGKLDR KRITAWIEKI DESIYDRIMQ DYDNIKRGNG NTEYKNEEDH
DSSINVLRDI FTQVLNIPSS KIDSTRSFVS LGGDSITGMA VISRARKHGL NLTLHNILQS
KSITELALTS TVIVQTIKHE EKSGELFDLS PIQGLFMQMT GKFQGRARFN QSMTVRLTKR
TRPDIVKNTI KAVVDRHSMF RARFSKSSDG NWQQTITKDI DSSYRFRTHS INSPSDMLPE
IAESQQCLDI QNGPIFAADL FEVRGHEQVL FVVANHLCVD MVSWRIVLQD MQEFIETGTL
SSDKPLSFQG WCDLQVENSK RENGVIQLPF SIEPPNLAYW GMANSQNLYG HVKMESFTLN
EEATAFILGR CHEALRTETV EILLSSVIHS FRRVFADRNV PTIYNEGHGR EAWDASIDLS
RTVGWFTTMC PLHVDGASDI INTLKRVKDT RRKIANDSRS YFAQSLLHPP ADGSTSFPVP
LEVVFNYLGQ LQQLERKDSL FQHYGGAFDA ETFELSGDMG PQTSRFALFE ISAIIIKDKL
HVSFTYNLNM QHRSRIQNWV SECRRTLEEE ILSLKDYSPA PTLSDYPLLP TTYGGLDDLV
KKTLPKAGVE SWDRVEDIYP CSPVQEGILL SQLRDPHGYM FHGIFEVRSL QGKHIDSALL
RKAWAMVVSR HPALRTLFID SNYKGGTFDQ LVIKAPGDDI LEFECDESLA FAKLDQVRLH
DINANRRIKL PQHLTICTTD SGRVLMKLEM NHAVVDGGSI DVLFRDLALA YNNQLPAGSG
PRYSDYIKYT RSQVHDKALQ HWKQYLAGVH PCHLSFSAKP RGYLCEHNSV TLANLTLSAW
AVVLRSFTGS DDICFGYPSA GRDSPVPGIH DAVGIFINML CCRVKFTSGQ TLEDVSKLVQ
SDYIGNLPHQ NCSLAQIQHE LGQQGQSLFN TTLSIQNRSA PQGPGDNIIS FEMQRAHDPT
EYPVTVNVET TKGREGIMLR YWKDTVSDSQ AKDLANAIAK VFTCFIERPS RLVSELKLTP
SHDSSAMDNS ALMDSDVLNS DALKKLIDIR VNEIITRMLK EGTLAIPTVH ELHIKASEGS
FRTKRMPRGG DLSDSTLTLT NYSRASTDTR ESTDLEKRLW SLWSSALGLS PNIVNRKGSF
FKLGGDSITA MKMVGAAREE GLSLSVADVF GNPVFEDMLA IVVAKDTPAV FETHTQAIQL
SEKVPESPVV ITRAVSPDEI SVLRPIPIDD SSLQSSICSK IGVFRGGIAD VLPVTDFQAM
SITASLFKSR WMLNYFFLDG KGPLDIRRLR ESFLQVVDAF DILRTVFVCF HGQFFQVVLR
KMRPIIVIHE TEQSLDEYTE SLQQRDREQD PRQGEQYVQF YVVKKKNTDH HRILIRMSHT
QFDGVCLPRI MSAIKLGYEG SPIPRTSSFS NYMRMLPGNI TPEHYQHWST LLQGSKMTDI
IRRQTPNNFQ HIGSFTAQKK AIEISATVIG DVTLATVMQS AWAMTLAKLS AQSDVVFGLT
ISGRNTTIPG IESTVGPCLN MIPVRVNFGD RWTGLDIFRY LQDQQVANMP YESLGFREII
RNCTDWPDST FFTTSVFHQN VEYEGHMQLD DNMYRMGGVG VVDNFTDITV VSKPTGDGKL
DITLAYSERS AITTPFAAKI LDMLCETAHS LITNPQITLP SPSTLRSLPC QVIDDLPRPT
EEHFLTSNLN SRSISELLVH SDILNKTWQH VLPNRHPETP RPPFQLNSSF FGLGGDIFSM
GQLAWGLEQE GLQVRLEELL EHPTFLGHLA VLALHNAKQE NLVERTRTVE SRAPAPSVSV
KGRTKSANWN PLGKALTLAR RFTKKRSSKS
//
