ID A0A1F8B7R4_9BACT Unreviewed; 572 AA.
AC A0A1F8B7R4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
GN ORFNames=A2892_03725 {ECO:0000313|EMBL:OGM59980.1};
OS Candidatus Woesebacteria bacterium RIFCSPLOWO2_01_FULL_39_10b.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802517 {ECO:0000313|EMBL:OGM59980.1, ECO:0000313|Proteomes:UP000176404};
RN [1] {ECO:0000313|EMBL:OGM59980.1, ECO:0000313|Proteomes:UP000176404}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM59980.1}.
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DR EMBL; MGHD01000010; OGM59980.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8B7R4; -.
DR STRING; 1802517.A2892_03725; -.
DR Proteomes; UP000176404; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR000977; DNA_ligase_ATP-dep.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR00574; dnl1; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR PANTHER; PTHR45674:SF9; DNA LIGASE 3; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 329..452
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 572 AA; 65161 MW; EB039DBE34530779 CRC64;
MDFRNLANFL EKLEKTRSRI EITKILASLF KKAEKGETEK ITNLLLGQLA PGYKGIVFNL
AERMMLQVIT QAYKKDLKEV KNLYKEEGDL GNVAGELAKG SSFKAKRKSI IEVYDFLLAI
AQDEGEGSQE RKIEKMARLL STLDPLSVRY VARIPVGKLR LGFSDKTILD ALSWLEKGDK
SAKSDLEKAY NVLPDVGLLV RKVKEVGIRK VSIGIAPVIG VPVLPMLAQR LKSPIEMIEK
MDKVAVEPKF DGLRIQLHYK SGKNGFIKAF TRNLNETSWM FPELESIGSQ VKTKELILDS
EAVGVDEKRK SLVNFQTTMT RRRKYEIEDI AKKVSIKFYV FDILHCDGKN LMNFSYLERR
KILDKTLVSG KLLEVVDYKI TKDSKVIEEM MRKELSEGLE GVIVKRANSR YVAGRTGWRW
VKMKEEETSY AKLVDTLDCI VMGYSVGKGR RAQFGVGQFL VGVLGIEKIK SITKIGTGIT
DDKFRELKKR LTKLEVKEQP KEYEINKDLK PDYWVTPSLV VEIAADEITK SPKHTSGYAL
RFPRLVKFRE DKSVDQATTV SEVERLFKFQ KL
//
