ID A0A1F8BM31_9BACT Unreviewed; 690 AA.
AC A0A1F8BM31;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=UvrABC system protein B {ECO:0000256|ARBA:ARBA00029504, ECO:0000256|RuleBase:RU003587};
GN ORFNames=A2893_05625 {ECO:0000313|EMBL:OGM65103.1};
OS Candidatus Woesebacteria bacterium RIFCSPLOWO2_01_FULL_39_25.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1802521 {ECO:0000313|EMBL:OGM65103.1, ECO:0000313|Proteomes:UP000176725};
RN [1] {ECO:0000313|EMBL:OGM65103.1, ECO:0000313|Proteomes:UP000176725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC lesions. Interacts with UvrC in an incision complex.
CC {ECO:0000256|ARBA:ARBA00026033, ECO:0000256|RuleBase:RU003587}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000256|ARBA:ARBA00008533,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM65103.1}.
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DR EMBL; MGHH01000007; OGM65103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8BM31; -.
DR STRING; 1802521.A2893_05625; -.
DR Proteomes; UP000176725; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd17916; DEXHc_UvrB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004807; UvrB.
DR InterPro; IPR041471; UvrB_inter.
DR InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR NCBIfam; TIGR00631; uvrb; 1.
DR PANTHER; PTHR24029; UVRABC SYSTEM PROTEIN B; 1.
DR PANTHER; PTHR24029:SF0; UVRABC SYSTEM PROTEIN B; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF12344; UvrB; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003587};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769,
KW ECO:0000256|RuleBase:RU003587};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003587};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881,
KW ECO:0000256|RuleBase:RU003587};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW SOS response {ECO:0000256|RuleBase:RU003587}.
FT DOMAIN 25..152
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 453..615
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 656..690
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
SQ SEQUENCE 690 AA; 78715 MW; F87DC7D5A4522F37 CRC64;
MNKFKLVSPY KPIPDQKKAV ESLVSGNKNN INHQVLLGVT GSGKTFTVAN VIEKLQKPTL
IISHNKTLAA QLYQEFRDFF PENAVSYFVS YYDFYQPEAY IPSTDTYIEK DADINELIDK
LRLAATTNLL TRRDTIVVAS VSCIYNIGSP RQYGHFVFEI GRGVKIHRRQ IIDRLIDLQY
ERGDFGFHRG TFRVMGDYID VYPAYQDEAV RIILGNDAIA DIEIFDPVSG SLIANHESPP
SNFVLYPAKH YITDPSQHED AFTQIQKDLF EQVKKLKASG KELEAYRLKT RVKFDLDMIK
EVGYVKGIEN YSRYFDGRAP GEAPYSLLDY FGFPYGNDWL VFVDESHITF PQIRGMYAGD
LSRKQTLVDY GFRLPSAYDN RPLKFDEFLR RIPNFIATSA TPSEWEISMA QESAKRSNKQ
KTMSKINIGV VEQLLRPTGI PDPEIEIRPV TGEVKDVIEE IKKVAKKGQR TLVTTLTKKT
AEDLSQYLTE QGMKVHYLHS DVATLERSDI LDDLRRGNYE ALIGVNLLRE GLDLPEVALV
AILDADKEGF LRSEVSLIQT MGRAARHVEG HVILYADNVT GSMQRAIGEV GRRRAYQIAM
NKKLAIVPSS ITKPIRERVI AEEEKGTIEK LFRQEVRSFA QLPEIDITSL TPMDKRKLIV
RLRREMKITA QDLNFELAAE IRDKIRQIEA
//
