ID A0A1F8EFR7_9BACT Unreviewed; 1615 AA.
AC A0A1F8EFR7;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN ORFNames=A2650_00890 {ECO:0000313|EMBL:OGM99692.1};
OS Candidatus Yanofskybacteria bacterium RIFCSPHIGHO2_01_FULL_41_53.
OC Bacteria; Candidatus Yanofskybacteria.
OX NCBI_TaxID=1802663 {ECO:0000313|EMBL:OGM99692.1, ECO:0000313|Proteomes:UP000177117};
RN [1] {ECO:0000313|EMBL:OGM99692.1, ECO:0000313|Proteomes:UP000177117}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGM99692.1}.
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DR EMBL; MGJD01000037; OGM99692.1; -; Genomic_DNA.
DR Proteomes; UP000177117; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR043993; T4SS_pilin.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF18895; T4SS_pilin; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 851..875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1053..1323
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 1062
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 1102
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 1275
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1615 AA; 170425 MW; D11800D6D4DEC129 CRC64;
MSVQFVHLYY ENGYAQAQSI QYAPILSQWS PSQGNGWFPQ LSPNGRYVAY GFGGSFIADI
QANQERTFGG SGCFGGWWIQ PDMATFNCET NATGTTADRY EVKVGQWTAN KTSDDPNLVS
GVLRAADGHW ASGLASNPTR ISKDNQLFST GNNWRISISG NNLATGCLNG DETEICLWES
ANQTKKFTAK TPNFETILKD KYIAYGGFGP VRGICLDDNK DIDLTATSSR QEHIGQIIMV
NSRPWIVTMT ETNGISAVLL RPWGERSSIV INAPTGPVSV STVYNNGIFT VAFNDNTGKL
SVVTVSDTAP RNDLSGGLAP ETCGVGAPVV GTPVNATAGW RGQLDYNPTN DTWLVVSDDY
SGGQGIIWGR IMANNQTPIT AQFSISGKSN SISPHVAYDK DKNRYLAVWI DLDTSQTEIF
GRFINSDGSF AGNPFLITRD FTDNPFFYPN APLRYDSVNK KFVLVWENRS PNIDIYLRTI
NPNTGQGDPT IKIVNSGGII GSAPSLAINE QANEYCIAYH CYGGSCTVSP NSSATAIRRV
DPQTGQVGQM TLAEINTAGE VSLAYNSTDN QYLATWKDIN SGPSVKGKIL SSCDGTDASS
GSFMVLNDAG SAINTYNPTS NTYAVVAQDQ SSIRNRFGQL DNRGVLLTSS YIFTDGTNGN
YSPFIAPNTR DGKYAAISSK DYAMVRFLSN LGVGSLAGLT AQSAPTPCDP SLNVPGYMIT
CNFSPSTVAP GGTVQVAGFN LATTVLLTSA AGTVTSLTGS VNSSNAILTF TVPSSMAESE
YEVTIEGNVT QIDGKRYFQS TYLGTLTVSS VPTTPNQPNQ PVPILPFQPN VGISIPPASN
FQDLINNAVK YSLYVIGIAV FIVFLWAGFL WMTSAANPGN IATAKSYMFN AVVGAVLLAS
SYVILYTINP ELVGGGFNFQ GIGSGPSGQS LITQPTCDNG FCSNNSSKAC TQNTDCNVVC
INNVCNNGTI GACTLDTDCQ IELKFVVHSE AEATSAFAAG CSRTTGSGYQ DFSAVECPDT
SANLTPDTVF QLQDTNVNNQ IGATITQTTG NKGQGTRIVI LDTGYNYNHP ELQSSYLGGW
DFVNNDNDPM DDHIGSVGAP GHGSHVAGII TSDGIDPQSI GVAPNSNIIS GKILDSNGAG
SYSAIINGIY WAINGPDNTY GTSDDFDPDA INISIGGGTY ANLCDNMDAT ALGISKAIQY
AKSHGVLVVI AAGNNPAGVS LPGCLSESFT VGAIDSNNLR ASFSGLGAGV DITAPGVNLY
SSILGNSYGT KTGTSMATPV VSGVVALIKS AFPNYTVDQV EQTIINSAVD LGSAGKDAFY
GWGKISANAM QGISTCSGAC ANITATPASC TKNVTISNPN CNITLNYSIS GITAGEAIIK
KNGIDWASLS GTSGSRAESN PPAGTYSYTL NNRVTGASLS STVVNIYYQG SLSSPWLACT
KGLSSTNPNC DVTLNYTLGT GSGNSIIYKD GFSWQNISPP SGSVTDTNVS AGTHTYTLRD
SSGSTQISRV VIRIEGPIPK PRIITSISPS SAKIGQVITI NGSNLGNALE VARKYFTVQV
HDKNRVRNTT TGKLDPSNTL GTWKVDPVLT PGEYTIRVGP LLNDTSNEVR FTVIP
//
