ID A0A1F8KX45_9CHLR Unreviewed; 493 AA.
AC A0A1F8KX45;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JUN-2023, entry version 20.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN ORFNames=A2082_06135 {ECO:0000313|EMBL:OGN78336.1};
OS Chloroflexi bacterium GWC2_70_10.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797615 {ECO:0000313|EMBL:OGN78336.1, ECO:0000313|Proteomes:UP000180316};
RN [1] {ECO:0000313|EMBL:OGN78336.1, ECO:0000313|Proteomes:UP000180316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGN78336.1}.
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DR EMBL; MGMI01000108; OGN78336.1; -; Genomic_DNA.
DR Proteomes; UP000180316; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09279; RNase_HI_like; 1.
DR CDD; cd01562; Thr-dehyd; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR48078:SF6; ACT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48078; THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT DOMAIN 341..480
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 323..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..482
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 51846 MW; C6748E057A1A3F18 CRC64;
MEEGQLVGLD DVQRAREVVA PHIQRTPLLS SRHLGERIGA QAWLKAESLQ RTGSFKPRGA
VYAVATMPEA DRQRGIVTMS AGNAAQAIAY AGLAVGARVV VAMPETAPAT KVAATRGYGA
EVRFGADTTK LMPIVRELEA AGMRFLHPFD DDAMIAGHGT VAVEILEDLP DVDLIVVPVG
GGGLIAGIAV AATALRPGIR VVGVEPEGAP GMRRALDAGR VVPLERPRTI ADALAAPFAG
ERPLEIVRRL VEDVVLVSDD EIAEGVRFLA ARARLVVEPG GAAAVAALLA GRAGVRPGER
VAVLVSGGNV DAARLAEILG ADGPALSSTP GGPGPRPQGA DRPRATLYAD GAARGNPGPA
GAGALLLDER GDTLAELHLA LGRATNNVAE YQALILGLEE AKKRGIERID VRMDSLLVVR
QMQGLWKIKH PGLRPLAVRA GALLAEFGDR TIEHVPREQN SXXXHRRSRR PRARRRGPRR
AARAARDRGW SGA
//
