GenomeNet

Database: UniProt
Entry: A0A1F8LN92_9CHLR
LinkDB: A0A1F8LN92_9CHLR
Original site: A0A1F8LN92_9CHLR 
ID   A0A1F8LN92_9CHLR        Unreviewed;       352 AA.
AC   A0A1F8LN92;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|ARBA:ARBA00020367};
DE            EC=6.3.3.1 {ECO:0000256|ARBA:ARBA00013047};
DE   AltName: Full=AIR synthase {ECO:0000256|ARBA:ARBA00032931};
DE   AltName: Full=AIRS {ECO:0000256|ARBA:ARBA00033093};
DE   AltName: Full=Phosphoribosyl-aminoimidazole synthetase {ECO:0000256|ARBA:ARBA00031908};
GN   ORFNames=A2Z74_04750 {ECO:0000313|EMBL:OGN87842.1};
OS   Chloroflexi bacterium RBG_13_46_9.
OC   Bacteria; Chloroflexota.
OX   NCBI_TaxID=1797619 {ECO:0000313|EMBL:OGN87842.1, ECO:0000313|Proteomes:UP000180311};
RN   [1] {ECO:0000313|EMBL:OGN87842.1, ECO:0000313|Proteomes:UP000180311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP
CC         = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) +
CC         phosphate; Xref=Rhea:RHEA:23032, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:137981,
CC         ChEBI:CHEBI:147287, ChEBI:CHEBI:456216; EC=6.3.3.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00023392};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004686}.
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
CC       {ECO:0000256|ARBA:ARBA00010280}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGN87842.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MGMM01000125; OGN87842.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F8LN92; -.
DR   UniPathway; UPA00074; UER00129.
DR   Proteomes; UP000180311; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd02196; PurM; 1.
DR   Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR   Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR   InterPro; IPR010918; PurM-like_C_dom.
DR   InterPro; IPR036676; PurM-like_C_sf.
DR   InterPro; IPR016188; PurM-like_N.
DR   InterPro; IPR036921; PurM-like_N_sf.
DR   InterPro; IPR004733; PurM_cligase.
DR   NCBIfam; TIGR00878; purM; 1.
DR   PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR   PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
DR   SUPFAM; SSF55326; PurM N-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OGN87842.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          79..165
FT                   /note="PurM-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00586"
FT   DOMAIN          177..343
FT                   /note="PurM-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02769"
SQ   SEQUENCE   352 AA;  38321 MW;  9CC2358F91BA3971 CRC64;
     MPKKSDKLTY AKSGVDRDTH SEITQGLKTQ LKMKDPRILN RVGAFASLFE ASFPGIKDPV
     LVLKAEEPGS KQLLARQFNK IEYIGFDMIN HLINDIIVMG AKPLAVLDVI IVGKLVKEEI
     NTIISAINQA CENQDCSLVG GEISEQPGVI PEGVFVLSSS VVGVVSKARI IDGSRIKKGD
     RVIALASNGL HTNGYSLVRK LIASKPAILK ARVNGEDFID AALKPHTAYY PYLKEILNSP
     KVRGLAHITG DGISGNLERI LPAGLSALVH LDKIEVHPIF KVIKEVGGVP ESDMIANLNM
     GVGMAMVASP VEEPGMMRYL ESKGIHAYHI GEIIEDKDNT VRYTGKVKWK TR
//
DBGET integrated database retrieval system