ID   A0A1F8MB53_9CHLR        Unreviewed;      1121 AA.
AC   A0A1F8MB53;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=A2Z77_04070 {ECO:0000313|EMBL:OGN95826.1};
OS   Chloroflexi bacterium RBG_13_51_36.
OC   Bacteria; Chloroflexota.
OX   NCBI_TaxID=1797625 {ECO:0000313|EMBL:OGN95826.1, ECO:0000313|Proteomes:UP000179678};
RN   [1] {ECO:0000313|EMBL:OGN95826.1, ECO:0000313|Proteomes:UP000179678}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGN95826.1}.
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DR   EMBL; MGMS01000047; OGN95826.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F8MB53; -.
DR   Proteomes; UP000179678; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   PANTHER; PTHR33841:SF4; ENDONUCLEASE-METHYLTRANSFERASE FUSION PROTEIN-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          389..498
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1121 AA;  127129 MW;  971CED7B371C21E7 CRC64;
     MGKEEEFNNI TVAATLAKDI RIVAERARNE EELRIGIEKL LDPALKKLGI AANPRYEKRI
     SRTVLTAVGR ADALYGQAII EYEPPGKLST AKGKNSTKKQ IEGYLLGLAG SGKQREDTLR
     RIAGIAIDGQ SIFFVRYRAD KPLPQETIPR EQLTQFPLFE EDAPQGSFVE IGPYQITEES
     VNEFLMYLRA LRRRRLTAEE LGKEFGPEGE VAHQMVNALY NRLEECLTAP ANLFPRVETL
     YEEWKRIFGI VYGQEIAKAQ KDALALARLY HIDQFTDLKP LLFAVHTYYA FFMKLLAAEL
     LSLQQGALLP SIAEQLPAAP SEVLQSSLHN LENNTWFEAQ GIRNFLEADF FGWYLSSWNS
     EIEEAIRNLA RCLAEYEPAT GTLAPEDTRD LLKKLYQYLL PRELRHDLGE FYTPDWLAEV
     VLSDVGYAGK PEMRMLDPAC GSGTFLVLAI RRIRDYAQSS MTSRAKGEHE LLNHILENIV
     GFDLNPLAVI SARTNYLLAL GNLARYMSGK DIPVYICDSV LTPQSQRTQK RPLAHQKDIP
     VPSAQKEFWI PEELVDKGKL DELCRMLEHC IEAKYDENEF ISLVQPQLKW EDPLTERSLV
     ELYKKVQRLK KEGRNGLWAR IIKNAFAPVF RTTSPFDYVV GNPPWVRWGY LSDEYREATK
     KLWVDYGLFS LKGMAARLGG GEKDFSMLFL YACADYYLRD GGRLGFVITQ EVFKAKGAGE
     GFRRFRLREE GAYLKVLKAG DMVTVKPFEN AANKTATIIL EKGMETSYPV PYIVWQRNKG
     IGNIDTATSL SDVIQLTIRK ELQATPIGDK TSSWQTAQVQ EKSALVKLKG ENFYEAKLGA
     RAEPYGIFWL KLRNVRSDGM LIIENLPEMG KRDIKKFENV NLESDLVYPA ARGRDINRWQ
     ANPGIYILIV QDPNTREGYP EKRMKNEWPE TYNYLQRFKH ELLSRGSRAV RELAEKTVFY
     SMYGIGPYTF APYKVVWKRM ATDLVAAVVS TFTTPFGDKV GIGTDTTSLI PFENEDEAHY
     VCALINSSVV GAFIRSFSSA GRGFGTPSIM NHLAVPGYEQ SNSLHRTLST LSKQAHQLAR
     QGKIGEVKLR QVENKIDEQA AKIWGLTDNE LAQISSFREI G
//