ID A0A1F8NMD5_9CHLR Unreviewed; 706 AA.
AC A0A1F8NMD5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Penicillin-binding protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=A2Y53_02880 {ECO:0000313|EMBL:OGO12020.1};
OS Chloroflexi bacterium RBG_16_47_49.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797639 {ECO:0000313|EMBL:OGO12020.1, ECO:0000313|Proteomes:UP000179729};
RN [1] {ECO:0000313|EMBL:OGO12020.1, ECO:0000313|Proteomes:UP000179729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO12020.1}.
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DR EMBL; MGNG01000087; OGO12020.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8NMD5; -.
DR Proteomes; UP000179729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..250
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 299..692
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 706 AA; 77343 MW; C551167AF1FC21C2 CRC64;
MKSSPALKNM VETWRIIFLG SLLVVIFFIY VARLYDLQVV QYSDWLAKSN ENRTHEINLP
ASRGTIYDRK GYIVARNIPS YNVVITPADL PDDTGEIQTI YREISNLTGI PVNRGEVSTS
DPYVPCISDH GITEIVTYGE TTAPYEPVKI TCDINQQIAL AIQENASTWP GVGIEVVPVR
DYPTGSLTAS IVGFLGPIPA IDEDYYRTMG FVPNRDKVGY AGVELYFQNL LAGVNGHRVV
EWDIAGQILD DLVPPVSSTP GSSIVLTIDT RLQQAVQSIL ADEINDWNRA LGEERMTSGA
VIAINPRTGE ILSLVNYPTY ENNRLARVIP AYYYQQLISD KRNPLLNLAV GAELPAGSVF
KLVTATGGLN EGIVTPEEII KTPGKITVTE RFYANDPGRP RDFVDWIYRT RPEGFGQLDF
VHAVANSSNV YFYKVGGGYQ DEVDPGLGIC RLGTYARALG YGTLPEGYAG LPAGYSTPEI
ELPDVASGLI PDPTWKRINQ GESWSTGDSY IVSVGQGYAL ATPLQVLLSA ATVANNGKLM
APTILYEILD SEGNIIQPFM PRLRWDLTVD PVIQSYEDNT IRGCQLTGKM KTVEPWVFDQ
IRTGMRLAVL EGTLKSIFTN VNIAAAGKTG TAEYCDEFAK AKNLCEPGNW PSHAWTVAFA
PYEDPEIAVV AFVYNGGEGA SVAGPIVRRV LEAYFELKSA DSTVIP
//
