ID A0A1F8PZ26_9CHLR Unreviewed; 840 AA.
AC A0A1F8PZ26;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A2Z16_09210 {ECO:0000313|EMBL:OGO28420.1};
OS Chloroflexi bacterium RBG_16_54_18.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797648 {ECO:0000313|EMBL:OGO28420.1, ECO:0000313|Proteomes:UP000177170};
RN [1] {ECO:0000313|EMBL:OGO28420.1, ECO:0000313|Proteomes:UP000177170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO28420.1}.
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DR EMBL; MGNP01000131; OGO28420.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8PZ26; -.
DR STRING; 1797648.A2Z16_09210; -.
DR Proteomes; UP000177170; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 2.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 342..561
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 627..754
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 409..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 93055 MW; 4F88ECF76774B75A CRC64;
MKQVCGWLLD VYPDLGGGKQ GRRGLLLWLL GEDGQRYCLR QTFPITFYAA GPPARLEALR
LFIESQPGGA PVTLFQTERK ELFSQRPLQV LAVQVDTVAS QALLFNRISQ AFPDLTYFDT
DIPLPLRHAA RFGTFPLARC AAAVDAQDTI QELQVLDSPW ELDPLEPPLR ILRMEPDPGP
VPAMPGPHAG GRPPTHLLLH TGQQGTLRLA LQPERPLLVN LRALLTRLDP DLLLTAAGDT
WMLPYLLERA RTARLPLPLN RDPVRQPAHR PERSYFSYGQ VIYRGRQVHL FGRWHIDRGN
AMLWDDYDLQ GVLEVARVTG LPVQTAARVS PGTGISSMQI LTALRNEILV PWHKQQAETP
KTALQMFAAD QGGLVYQPLV GLHHDVGEID FVSMYPGIMV HFNISPETVR SHGPSWQSQG
SSTPDRSLTP FPQPDPAPGE TSTPAVALPA DELLKTPPPL PAAGDDPDDQ LGLIPKTLSP
LLDKRLALKA HLAAMRTDPS QRWDPRCRAY EARASAHKWL LVTCFGYLGY KNARFGRIEA
HEAVTAYGRE ALLRAKEAAE DLGFTVLHLY VDGLWVKKPG ASRVADFQPL LDAISERTGL
PIALDGVYRW VAFVSSRIDA RWPVPNRYFG VFQDGSLKVR GIEARRDDTP PFITEVQMQL
LELLAKQTAA GTSQTGEAPT YDLAPALDLL RRKLAALRQG RVPLHELVVN QRLSQEIEAY
RQPSAAARAA MQLQSLGSSF RPGQRVRFLY TLGKPGVAAW DLPPYPAALD LKRYTRLLLR
AAHAALGPFG VSEAQLGQLV TDLPARQLKF SQEVLATRLK NYIVNQKNQI PPSGAAESPR
//
