ID A0A1F8Q014_9CHLR Unreviewed; 718 AA.
AC A0A1F8Q014;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN ORFNames=A2Z16_12405 {ECO:0000313|EMBL:OGO28803.1};
OS Chloroflexi bacterium RBG_16_54_18.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797648 {ECO:0000313|EMBL:OGO28803.1, ECO:0000313|Proteomes:UP000177170};
RN [1] {ECO:0000313|EMBL:OGO28803.1, ECO:0000313|Proteomes:UP000177170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO28803.1}.
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DR EMBL; MGNP01000123; OGO28803.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8Q014; -.
DR STRING; 1797648.A2Z16_12405; -.
DR Proteomes; UP000177170; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 253..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 464..611
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT REGION 675..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 78471 MW; E4DFD2996FEAFF42 CRC64;
MLVLVLLVSV PLAWFATALP LLSNSSAPLL QEGQVADRDY RASETATYTS SVMTEQRHEI
AVRSVAPIFT SPDSRVARKQ LESMRNVLAY INTVRADPYA SITQKTSDLQ AMEDILLEAD
TALTLLGLTD SRWQAVQQEA LVVLEKIMSS PIRPDGIQDS RSRLPALVSL ALPETQADVV
AALVEPFVTP NSFYSDELTQ AAQQAARDQV EPLSRTFVAD QVIVFRGEVL DAADIEALQQ
LGIVKPEEIL PDLASITALV LLMAVYMVLY FRRERAEQSS NRRAVPVVSL LFLVFLFGSR
LILPSHTVLP YAFPAAAYSL TVAALYGSRL ALISTLPLAI LMAYGLPNAL ELTLYFIMGG
LFGVLAVGRA RRMASFFWAG VAIAFAGIMT VLVFRLPLPT TDLVGLATLC GASLVNGLAS
GSITIVLQYA LAQFMGMTTP MQLVDLTRPD HPLMQQLLKK APGTYQHSLQ VANLAEQAAE
RIGADSLLTR VGALYHDVGK TGNPLFFIEN QTPGFSSPHE TLTGSQSAEI IIRHVTEGLE
LADRHRLPRA IREFIEQHHG TLTARYQYVQ AVKEAGGDER QVDIELFRYP GRIPQSREVA
ILMLADGCEA RVRAERPSNE EQLLEVIKSM VKDRFAKGQL DETNLTFRDL TLIQDSFLSS
LRVIYHPRVR YPNEEVSISP DTAPSRGTMG SELPSGSGLE AGLPVDGAPK VAHGTEPA
//
