ID   A0A1F8QHH5_9CHLR        Unreviewed;       814 AA.
AC   A0A1F8QHH5;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   13-SEP-2023, entry version 14.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   ORFNames=A2Z16_06685 {ECO:0000313|EMBL:OGO34905.1};
OS   Chloroflexi bacterium RBG_16_54_18.
OC   Bacteria; Chloroflexota.
OX   NCBI_TaxID=1797648 {ECO:0000313|EMBL:OGO34905.1, ECO:0000313|Proteomes:UP000177170};
RN   [1] {ECO:0000313|EMBL:OGO34905.1, ECO:0000313|Proteomes:UP000177170}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGO34905.1}.
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DR   EMBL; MGNP01000009; OGO34905.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F8QHH5; -.
DR   STRING; 1797648.A2Z16_06685; -.
DR   Proteomes; UP000177170; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.30.1900.20; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          67..324
FT                   /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT                   /evidence="ECO:0000259|Pfam:PF07733"
FT   DOMAIN          328..494
FT                   /note="DNA polymerase III alpha subunit finger"
FT                   /evidence="ECO:0000259|Pfam:PF17657"
FT   DOMAIN          571..651
FT                   /note="DNA polymerase helix-hairpin-helix motif"
FT                   /evidence="ECO:0000259|Pfam:PF14579"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:OGO34905.1"
SQ   SEQUENCE   814 AA;  90737 MW;  6E5A1D502AE5E3BB CRC64;
     DSIQKEDPIS SQAHFMSTEE IEAGYHDSPG AIHMVAEIIE RCQPALPVGS PHLPEVETPV
     GLNSSQLLRK KADQGAIQLY GEITPSIRQR LEHELQVIES LGYSSLFLIV EEILSFAREK
     GVPFSSRGSA ASSLVAHCLG ITSPDPLRLN LYFERFLNPA RASLPDIDID LCSRRRDEVI
     EFVYRKYGRE RVAMVCTINR FRRRSALREA AKAHGLQQAE INRMVESLPH RWYGPADRDN
     PDDQPYEELA NQFQSPLQQS IILAASALLG VPHHLSIHPG GIVISPDAIT DLTPIQLATK
     GMLITQFDLE SIEQLGLVKI DLLGIRGLTV LGDVVEAINA GYDSQPRSQL GSLDDIPEED
     RDTSELVRAG KTIGCFQIES PGMRLTLKEI QASSLDGVMA ALALYRPGPL TGGQKDNFIR
     RFQGRETTSY LHPSLAPLLE DTYGVILYQE QVLRIAHKLA GLSLADADLL RRAMSHFDPG
     KQMQTLKEKF IQGTFDLHGI PQTTSEQIWE LMAAFAGYGF PKAHAASYAR VAWRSAWCKV
     HHPAIFMAAV LANWGGYYSQ SNYLTEARRM GLKLKPPHVN YAQHEFSVSY QQGKPVLFMG
     LDQIRDLSNR TQKRILRERP FRSFEDFLTR TDPRIQEAEN LVKVEALEGM GTIPALLGRL
     SLGGWQGGQL SLFGAPDTGA EDFSIAEKAR AQEEILGASV IAHKLELFTD QISESKALTT
     VEAVARIGQQ VRVAGIRQFW RRSSTSKGEP IYFMSLEDLE GTLQVVIIAE VYRRCRSELR
     LAGPYVIEGS MEMDTRQIEP SLHAERIWAL NTPD
//