ID A0A1F8RH68_9CHLR Unreviewed; 484 AA.
AC A0A1F8RH68;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=4-hydroxybutyryl-CoA dehydratase {ECO:0000313|EMBL:OGO46987.1};
GN ORFNames=A2Z30_08015 {ECO:0000313|EMBL:OGO46987.1};
OS Chloroflexi bacterium RBG_16_64_43.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797659 {ECO:0000313|EMBL:OGO46987.1, ECO:0000313|Proteomes:UP000179556};
RN [1] {ECO:0000313|EMBL:OGO46987.1, ECO:0000313|Proteomes:UP000179556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO46987.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MGOA01000131; OGO46987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8RH68; -.
DR STRING; 1797659.A2Z30_08015; -.
DR Proteomes; UP000179556; Unassembled WGS sequence.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 2..271
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 279..477
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 188
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 484 AA; 52590 MW; BAC4E76D605D6AC2 CRC64;
MTRNDYVASL DSMHKQVYFQ GEQVSDPVNH PMLRPSLNAC AMTYTLAEAP EHTEIMLAHS
ALTHRPVNRF THLHQNPADL VAKVKMLRLL GQTTGCCFQR CVGMDALNAL DSVTYEMDQQ
LRTEYHLRFM EFLSAVQEGD RVVGGAMTDA KGDRHLRPSQ QADPDLFVRI VERRAEGIVV
RGAKLHQTGA VNAHEILVMP TLALAQGEEE YAVACAIPAD APGVLMIVGR QPSDGRRLEA
GRLDMGNPEF GGHEAVIILE DVFVPWQRVF MAGETAFSGM LVERFAAYHR QSYGGCKAGV
GDLLIGATQA LAQIQGTATA AHVRDKIVEM VNLNETLYAC GIACSGEGRP AASGTYLVDP
LLANVCKLNV TRAPFEMARL AQDIAGGLLV TLPSEKDLAS PVTGPYLRKY LRGTPSASME
ARYRMLRLVE NLTLGAGAAA YLTESMHGAG SPQAQRIMLA RLADLPAKVE IAKRLAGIQD
ESIQ
//
