ID A0A1F8S0Q5_9CHLR Unreviewed; 575 AA.
AC A0A1F8S0Q5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|RuleBase:RU000612};
GN ORFNames=A2V84_08560 {ECO:0000313|EMBL:OGO53470.1};
OS Chloroflexi bacterium RBG_16_70_13.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797662 {ECO:0000313|EMBL:OGO53470.1, ECO:0000313|Proteomes:UP000177511};
RN [1] {ECO:0000313|EMBL:OGO53470.1, ECO:0000313|Proteomes:UP000177511}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|RuleBase:RU000612}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO53470.1}.
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DR EMBL; MGOD01000090; OGO53470.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8S0Q5; -.
DR STRING; 1797662.A2V84_08560; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000177511; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
SQ SEQUENCE 575 AA; 60472 MW; AAD7273CCDA64645 CRC64;
MSAEFDLRLA PADEGRLAAV AAHARRDDWA RRLMDRDTSL WTDEPAARAA IAERLGWLDA
PAHFTDQIAA LEGFGDGIRV AGFRTAVVMG MGGSSLAPEV LHRTFGTAEG YLDLRVLDST
DPAAVAATVD DLDPLATLWI VASKSGATTE PLAFLADAWA RLEAALEASG SDQRPGDFVV
AITDPGRSVM AIPHHDELRE VFLNPPDIGG RYSALSYVGL VPASLIGLDL DALLASASTM
LAACREPDPE RNPGLLLGLA LGELGRAGRD KLTFLADPTL ASFGAWAEQL IAESTGKHGV
GIVPVDREPL GDAGSYGADR AFVRLSLAGA PDPSSGLLDA LAAAGHPVIR LVIDDPMDLG
GEFVRWEVAT AIAGAVLDID PFDQPNVEEA KERTRRVLAT ASVGVLAGTD VASAAAAAAG
PELLWIEELG EVALGEAVAA SLGARKAGRY VGLQAFIAPS PERDAAFDRL RALIRDRTGY
ATTAGYGPRF LHSTGQLHKG GAPIGWFLQL TEEHPDDREI PGWPYSFGRL IDAQAQGDAE
SIAAHGLPIL RLRLGRDAAA DLAMLQRAFN RALGG
//
