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Database: UniProt
Entry: A0A1F8S6Y4_9CHLR
LinkDB: A0A1F8S6Y4_9CHLR
Original site: A0A1F8S6Y4_9CHLR 
ID   A0A1F8S6Y4_9CHLR        Unreviewed;       295 AA.
AC   A0A1F8S6Y4;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   13-FEB-2019, entry version 9.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=A2V85_12705 {ECO:0000313|EMBL:OGO55632.1};
OS   Chloroflexi bacterium RBG_16_72_14.
OC   Bacteria; Chloroflexi.
OX   NCBI_TaxID=1797663 {ECO:0000313|EMBL:OGO55632.1};
RN   [1] {ECO:0000313|EMBL:OGO55632.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGO55632.1}.
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DR   EMBL; MGOE01000107; OGO55632.1; -; Genomic_DNA.
DR   UniPathway; UPA00121; UER00345.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN       11    186       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      211    290       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        179    179       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   295 AA;  31420 MW;  4F77D7228CEA2383 CRC64;
     MTGDRTSRRP VVGYTGEPGA FAEEAVLRFF AAPEARALSS FRAVFEAVRE GGADAGVVPV
     ESSLLGTIRE NLDLLYEFGL PIVGEVSVPV RLALLALPGE RLETIDRVYS IAAALAQADE
     FLRSRPWTIQ TTYNTAGAAK QVAERGERGA AAVASARVAP IYGLEVVADG IQSGDDNRTR
     FAVIARTGAE AVAAVRAAAS PVAVAGPPKT TLVFAVRNVP GSLHRSLGAF ASRGINLSRL
     ESRPWADRGS RWEYLFWVDL DADPIDVACA AALDELGRET ELVRILGTYP RAPED
//
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