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Database: UniProt
Entry: A0A1F8SKL5_9CHLR
LinkDB: A0A1F8SKL5_9CHLR
Original site: A0A1F8SKL5_9CHLR 
ID   A0A1F8SKL5_9CHLR        Unreviewed;       382 AA.
AC   A0A1F8SKL5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   16-JAN-2019, entry version 11.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:OGO60191.1};
GN   ORFNames=A2Z36_03575 {ECO:0000313|EMBL:OGO60191.1};
OS   Chloroflexi bacterium RBG_19FT_COMBO_48_23.
OC   Bacteria; Chloroflexi.
OX   NCBI_TaxID=1797666 {ECO:0000313|EMBL:OGO60191.1};
RN   [1] {ECO:0000313|EMBL:OGO60191.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGO60191.1}.
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DR   EMBL; MGOH01000063; OGO60191.1; -; Genomic_DNA.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 2.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   DOMAIN        8    188       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      191    285       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      308    378       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      13     18       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      36     36       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      52     52       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING      59     59       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING      96     96       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     101    101       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     123    123       Coenzyme A. {ECO:0000256|PIRSR:
FT                                PIRSR000105-3}.
FT   BINDING     123    123       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     147    147       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     277    277       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        144    144       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   382 AA;  42211 MW;  7DFA4E1F5C231801 CRC64;
     MKVEDIKKIA VMGAGDMGHG IAEVALLAGY KVAMRDIEQR FVDKGLTRIK ESLDKLTEKQ
     KITADNNKAM VANIETFVDI DKAVKDADFV IEAVPEVMDL KKQVFEALDK AAPKHTILAS
     NTSNMSVTEI AATTQRPEQV VGMHFFNPAV LMKLVEIIKG DKTSEETMKV AYDLALKMNK
     VPVRVEKDSI GFVYNRVNAP NGILLGEIIE RGWATPEEID AKMRKMGMPM GPYELMDYVG
     LDVAYHSASY FAERLSPDFK PRKWMKAKMD AGTLGKKSGK GIFDWSKGRP EIDLSKAKED
     FDPTDMIAIQ VNEATKLLED GVVKSADEID KAMVNGGGAV FGPFQLAKGI GYDKLAQRCD
     ELAKKYGIKT FEPTETLKSG KI
//
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