ID A0A1F8ST35_9CHLR Unreviewed; 486 AA.
AC A0A1F8ST35;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=4-hydroxybutyryl-CoA dehydratase {ECO:0000313|EMBL:OGO63065.1};
GN ORFNames=A2030_05170 {ECO:0000313|EMBL:OGO63065.1};
OS Chloroflexi bacterium RBG_19FT_COMBO_50_10.
OC Bacteria; Chloroflexota.
OX NCBI_TaxID=1797668 {ECO:0000313|EMBL:OGO63065.1, ECO:0000313|Proteomes:UP000177637};
RN [1] {ECO:0000313|EMBL:OGO63065.1, ECO:0000313|Proteomes:UP000177637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGO63065.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MGOJ01000140; OGO63065.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F8ST35; -.
DR Proteomes; UP000177637; Unassembled WGS sequence.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR Gene3D; 1.10.3140.10; 4-hydroxybutyryl-coa dehydratase, domain 1; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR InterPro; IPR004925; HpaB/PvcC/4-BUDH.
DR InterPro; IPR024719; HpaB/PvcC/4-BUDH_C.
DR InterPro; IPR024674; HpaB/PvcC/4-BUDH_N.
DR PANTHER; PTHR36117; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR36117:SF3; 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED; 1.
DR Pfam; PF03241; HpaB; 1.
DR Pfam; PF11794; HpaB_N; 1.
DR PIRSF; PIRSF000331; HpaA_HpaB; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR000331-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 11..277
FT /note="HpaB/PvcC/4-BUDH N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11794"
FT DOMAIN 287..482
FT /note="HpaB/PvcC/4-BUDH C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03241"
FT BINDING 195
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000331-2"
SQ SEQUENCE 486 AA; 53786 MW; 62DDE700E8FC7F6E CRC64;
MSDDIHQKIV TGEDYIDSLR SRKLKVFLMG EQVDEPVNHP MMRPSVNAMA MTYDLALETP
ALCTTLSPIT GEPVNRFLHV SMSAEEVVQQ NRLQRRLGQL TGTCFQRCVG MDALNALYSV
TFEIDAKYGT PYHYRLKAFI KAMQTHNYVI GGAMTDVKGN RNKPPSQQAD PDMYVHVSRR
TQDGVYIRGA KAHQTGAVNS HWLIVMPTLS LQSDEADYAI VGALPVNADG ITYVVGRQSC
DTRCLEGEID SGNAGFSGQE ALIIFEDVFI PNETIFMDGE VEFSALLVER FTAFHRRSYV
CKSGVGDVLI GAAATAAEYN GVDKASHIRD KLVEMTHLNE TIYATGIASS YQSLPTPSGA
YQCDELLANV CKQQVTRITY EIARLAQDLA GGLLVTLPSE ADYRNEELGP KLEKYLKGRE
DVPTENRMRI LRLIENLTMG RNAVGYLTES MHGAGSPQAQ RIQIQRQMDL AFKQSLAKHL
AGVEEG
//
