ID A0A1G0CZD1_9PROT Unreviewed; 349 AA.
AC A0A1G0CZD1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:OGS94043.1};
GN ORFNames=A3K04_07900 {ECO:0000313|EMBL:OGS94043.1};
OS Gallionellales bacterium RBG_16_56_9.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales.
OX NCBI_TaxID=1798249 {ECO:0000313|EMBL:OGS94043.1, ECO:0000313|Proteomes:UP000177554};
RN [1] {ECO:0000313|EMBL:OGS94043.1, ECO:0000313|Proteomes:UP000177554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGS94043.1}.
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DR EMBL; MGWU01000265; OGS94043.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G0CZD1; -.
DR Proteomes; UP000177554; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30566:SF25; INNER MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR30566; YNAI-RELATED MECHANOSENSITIVE ION CHANNEL; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..178
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 180..246
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 253..337
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 349 AA; 38863 MW; D5BDD4DE53525373 CRC64;
MQAMLNESIF GNTVLDYLSS LAIFIGGIVI AYAFKRYVLY RLKMLADSTD TPIDDFLVSA
IQKTLLPVFH FGVFYLSVQA LNLTPRLERG LEIAAIILVI VLAARTVTSI VDHALQSYMK
KSADSSGWEK QLKGIRGLLN FSIWVIALGF LLDNLGVKIT GLVAGLGIGG IAVALAAQTV
LGDLFSYFVI FFDKPFEIGD FIIIGDKMGV VEKIGIKTTR IRALGGEQMV FSNTDLTNSR
VHNYKKMEKR RVIFSLGVIY QTSSEKLKTI PQMIKEIIGQ QEDAAFDRGH FASYGDFSLN
FEFVYYVTGA DYNKYMDIQQ AINLAIFEAF EKTGIEFAYP SQTLFCKQG
//
