ID A0A1G0RAX9_9BACT Unreviewed; 648 AA.
AC A0A1G0RAX9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Ferrous iron transport protein B {ECO:0000256|ARBA:ARBA00031200, ECO:0000256|RuleBase:RU362098};
GN ORFNames=A2X64_10790 {ECO:0000313|EMBL:OGU57288.1};
OS Ignavibacteria bacterium GWF2_33_9.
OC Bacteria; Ignavibacteriota; Ignavibacteria.
OX NCBI_TaxID=1798430 {ECO:0000313|EMBL:OGU57288.1, ECO:0000313|Proteomes:UP000179061};
RN [1] {ECO:0000313|EMBL:OGU57288.1, ECO:0000313|Proteomes:UP000179061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU362098}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC {ECO:0000256|RuleBase:RU362098}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGU57288.1}.
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DR EMBL; MHAC01000064; OGU57288.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G0RAX9; -.
DR STRING; 1798430.A2X64_10790; -.
DR Proteomes; UP000179061; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.1770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003373; Fe2_transport_prot-B.
DR InterPro; IPR041069; FeoB_Cyto.
DR InterPro; IPR030389; G_FEOB_dom.
DR InterPro; IPR011642; Gate_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00437; feoB; 1.
DR PANTHER; PTHR43185:SF1; FE(2+) TRANSPORTER FEOB; 1.
DR PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR Pfam; PF17910; FeoB_Cyto; 1.
DR Pfam; PF02421; FeoB_N; 1.
DR Pfam; PF07670; Gate; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51711; G_FEOB; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|PIRSR:PIRSR603373-1,
KW ECO:0000256|RuleBase:RU362098};
KW Ion transport {ECO:0000256|RuleBase:RU362098};
KW Iron {ECO:0000256|RuleBase:RU362098};
KW Iron transport {ECO:0000256|RuleBase:RU362098};
KW Magnesium {ECO:0000256|PIRSR:PIRSR603373-2};
KW Membrane {ECO:0000256|RuleBase:RU362098};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR603373-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR603373-1};
KW Transmembrane {ECO:0000256|RuleBase:RU362098};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW Transport {ECO:0000256|RuleBase:RU362098}.
FT TRANSMEM 294..320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 341..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 400..416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 456..477
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 517..540
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 595..616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT TRANSMEM 623..646
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362098"
FT DOMAIN 15..175
FT /note="FeoB-type G"
FT /evidence="ECO:0000259|PROSITE:PS51711"
FT BINDING 22..29
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT BINDING 36
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT BINDING 66..69
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
SQ SEQUENCE 648 AA; 73459 MW; 03F0B178FCEE241B CRC64;
MKFLNTQIPQ NIEPSKKIAL VGLTNSGKSS IYRFLTDFQG KPYYDSTFEL TSHSAIIENN
LCDVIDLPGI QSLNSTKPSE KITIEFLLNE KIDILINVID STMLSRGLKF TLELLDLGIP
TILVITFNDE AKKRGIRVDL NLLSKILNIS VISMNGRMGS GIADLSKTIN ENLQRPFSPT
QFEFTHHIET EIQKLQNLIQ DENSQLNGNK RFKSLQLINN NKYFIYLRNS QINELIDNIS
KKILEEHHKS LFETISYERH HIAMQITEEV APLTQKNKIQ LPDKIDAVIS HPRFGYVVLI
AVMFLIFFLI FYIGNFLSGI IEPPIQQLNR LFDVYKTTSP FLWNTINGAF MGIIGAVGIV
LPYFLPLVFL NSLLEETGYM SRIVLLIDNL MHKIGLHGKS ITPFIMGLGC SVPAIYSTRM
LENKRDRIIT AILIPFIPCS ARLTVIFALA TAFVGPIWVI IIFAYLMIII ALGSIGLSKI
LPESTGLIME ILPLKLPSLK MSILRTYSKL NEFLKEAFLF LILGGIVLGW IEFFNITYYI
DLFFSPIIKT ILDLPQELGS TLVFGFFRKE LILVMANQAL GVNEIKDLPL TSSQIIQFII
FVSLYFPCLS TFIVLLKEYK WKITIFSSVV SVIVALLSAI LFRLIFSI
//
