ID A0A1G0SSV8_9BACT Unreviewed; 440 AA.
AC A0A1G0SSV8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN ORFNames=A3G43_13995 {ECO:0000313|EMBL:OGU75483.1};
OS Ignavibacteria bacterium RIFCSPLOWO2_12_FULL_56_21.
OC Bacteria; Ignavibacteriota; Ignavibacteria.
OX NCBI_TaxID=1798438 {ECO:0000313|EMBL:OGU75483.1, ECO:0000313|Proteomes:UP000177278};
RN [1] {ECO:0000313|EMBL:OGU75483.1, ECO:0000313|Proteomes:UP000177278}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGU75483.1}.
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DR EMBL; MHAK01000040; OGU75483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G0SSV8; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000177278; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.20.28.60; -; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 323
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 379
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 440 AA; 49870 MW; DA80087DBC079CC3 CRC64;
MPTTIAEKPS AEVPAGAALE TLKITDSRTG KSYEIPIEHG TVKAIDLRQI KTGPEDFGLM
TYDPAFMNTA SCRSKITFID GEKGILLYRG YPIDQLAEKC SYLQVAYLIL YGELPTVTQL
HEWTEHVRMH TFVHENVKRL MDGFRYDAHP MGIFVSTLAA LSTFYPEAKN VLDADTRQKQ
VWRLIGKVPT IAAFAYRHSL GMPYVYPDND LTYAENFLSM MFRVAESKYR PNRVLARALE
VLFILHADHE QNCSTNAMRS IGSSQSDPYC SAAGAAAALY GPLHGGANEA VLRMLDEIGS
KANVPAFVRD VKEGKGRLMG FGHRVYKNYD PRAKIIKRMA DEVFAETEKN PKLEIALELE
RIALEDEYFV KRKLYPNVDF YSGLIYQAMK FPVDMFPVMF AIPRMSGWLA QWEEMLMSPE
QKIARPRQMY LGAQRRNVPA
//
