ID A0A1G0YT46_9BACT Unreviewed; 1198 AA.
AC A0A1G0YT46;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A2017_08075 {ECO:0000313|EMBL:OGV49133.1};
OS Lentisphaerae bacterium GWF2_44_16.
OC Bacteria; Lentisphaerota.
OX NCBI_TaxID=1798571 {ECO:0000313|EMBL:OGV49133.1, ECO:0000313|Proteomes:UP000176916};
RN [1] {ECO:0000313|EMBL:OGV49133.1, ECO:0000313|Proteomes:UP000176916}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGV49133.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MHBF01000126; OGV49133.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G0YT46; -.
DR STRING; 1798571.A2017_08075; -.
DR Proteomes; UP000176916; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1198 AA; 135305 MW; 11B7024C0EF45A73 CRC64;
MPSEFVHLHL HSDYSLLDGA CSVSGIVKMA EAYKMRAVAM TDHGFMGGLI DFYQQMNAAK
IKPIIGCEAY ISPTTRFDRD PNNPNIRGFH VVLLAKNEAG YKNLCKLIAE ANLNGMYYKP
RIDREILAKH HDGLIALSAC IKGEIPSAIL DGKIKDAKRI LREYLDMMGK ENFYLEIMDH
GLEEQKKINR ELILLSKEFD VPLVATNDVH YLKEEHAKAH ELMLCIQTRS TINDPKHFKF
SSDQFYFKNG VEMRELFKEV PEAVKNTLEV AEKCNVVFTF APAANHYPVY QIEGNTDRKK
YLRDICLQGI RERYGFEPLD AGLDAEKKKT LERMDYELNI IDNSHYTSYF LVVWDFLRYA
KQSGIPVGPG RGSGAGSIVA YLTRITDVDP LRYKLLFERF LNPERISPPD FDIDFCERRR
TEVIEYVRKK YGAENVAQIG TYGTLKAKAV IKDIARVTGH SIAESDLITK LIPNDPKMTL
KKAIEASSEM RELINKEAWV KEIFDYAEAL EGLNRNMTIH AAGVIIGDQK LNGLVPLAKG
SAGEIITQYS AKPCENLGLL KMDFLGLKTL TIIQDAIDNI KKFRGQEIII DNLPLDDQPT
FNLLNRGDTV AVFQLESDGM QNLCRQFGVE TIEHIIALIA IYRPGPMEFI PDFVSRKMGQ
STFEYEHPAM EPILKETYGI MLYQEQVMQI VQALAGFTPG QADTLRAAIS KKKVKDIELL
KAKFLKDAPP FTKISEKTAN IIWEKIAKFA GYGFNKSHSA AYAFLAYRTA YLKANYPVEF
MTAVLASEID NAEKIAFFIN ECREMEISIL PPDVNSSDIN FTVNGSSIRF GLGAIKGVGS
NAANAIISSR EKEGPFKSML DFCERAGSSV NTRMLEHLIR SGAFDTFKVK RSQLIEITGA
VLSMAQSTIK DKESGQGSLF DMLPEAERED TFAIPLPDIP EFDENEMLKD EKALLGFYVT
GHPLAKYAEL IKTFSTVNLL KAKTLEHDTG IKIGGIIKSV QKRRSKKDDK PYAIVQLEDL
EGSMECMVYN KLFEKELDED LRENDSTIFV KDLLEDEKPI FVEAFVNQRD ENEVKKLIAE
KIVPMSAVSK KYTRELHLHV FEVSTKHKDL EDIKELCGKH PGESRVIFCV KCANGDIAYL
ESSDKTKVSV DETLLHKIQE VLGERRYKLK ADKAVPIQKN RFYRNGANGK NGQEAPSQ
//
