ID A0A1G0ZAC2_9BACT Unreviewed; 175 AA.
AC A0A1G0ZAC2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=HIT domain-containing protein {ECO:0000259|PROSITE:PS51084};
GN ORFNames=A2X45_23450 {ECO:0000313|EMBL:OGV55163.1};
OS Lentisphaerae bacterium GWF2_50_93.
OC Bacteria; Lentisphaerota.
OX NCBI_TaxID=1798574 {ECO:0000313|EMBL:OGV55163.1, ECO:0000313|Proteomes:UP000178497};
RN [1] {ECO:0000313|EMBL:OGV55163.1, ECO:0000313|Proteomes:UP000178497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGV55163.1}.
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DR EMBL; MHBI01000089; OGV55163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G0ZAC2; -.
DR STRING; 1798574.A2X45_23450; -.
DR Proteomes; UP000178497; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 30..138
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 123..127
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 125
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 55
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 127
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 175 AA; 19649 MW; 86445B6A9C1281D6 CRC64;
MAAVNKRPLW APWRIDFVTS PKPDRCFLCS KNRRFGGDEE ELIISKGRHV FAILNRFPYN
SGHLMIVPYK HVGSLMLLDK KVLYELMDMT LRAQAVMTAV MRPAGFNIGF NIGAAAGAGL
EDHVHLHVVP RWAGDTNFMP VLGDARVVPQ ALKDTAAILR TAWNRKVGLE NKKKK
//
