ID A0A1G1CAW9_9BACT Unreviewed; 695 AA.
AC A0A1G1CAW9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=A3K19_11180 {ECO:0000313|EMBL:OGV91658.1};
OS Lentisphaerae bacterium RIFOXYB12_FULL_65_16.
OC Bacteria; Lentisphaerota.
OX NCBI_TaxID=1798581 {ECO:0000313|EMBL:OGV91658.1, ECO:0000313|Proteomes:UP000179250};
RN [1] {ECO:0000313|EMBL:OGV91658.1, ECO:0000313|Proteomes:UP000179250}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGV91658.1}.
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DR EMBL; MHBP01000108; OGV91658.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1CAW9; -.
DR Proteomes; UP000179250; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 4..283
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 284..566
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 673..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 695 AA; 78076 MW; 6BA3D35F350AEF50 CRC64;
MNLRDLNEPQ RQAVCTVDGP LLLLAGAGTG KTRVITSRIA YLVSRGIAPG NILAVTFTNK
AAREMKERVA KLLSADAARA VTVGTFHSFC ARLLRKKIHL LGYRPNFAIA SEAYRAGLIR
TLMAELGLTG EGRDPASWLA TISKAKGALS GPDELGARDD LPHAGAIAEV YALYDRRMKQ
MNLVDFDDLL GLVLKLWEEK PDALAEHRNQ YHYLLIDEYQ DTNRVQFQLM ATLAGERRNL
CVVGDDDQSI YAWRGADITN ILEFERHFPS ARVITLEQNY RSTTTILDAA GQVIANNRAR
RPKRLWSTRG AGNKIQAVRV GDDEEEARFV VDLLREHRLH PGMTYGQCAV LFRSNHLSRA
LENQFRQSRL PYVLVGTRSF FERKEILDVV SLLQAVDNPD DDLSLLRILN VPPRGIGDKA
VERLRHWQRV TNLPLQQLLA ESEFLAELPP ATAASVRAFH RCLMDARTRF ETPGHLTQNL
LGLLEDSGYL EGLGRMYKPR EDALRRRDNV LEFVNEMAEY VRRAGAAATL RDFLESFALL
DTNDREEKDS AAEDAVTLMT VHAAKGLEFT LVCVVGMERG LFPHQRALEE HAEDEERRLF
YVALTRARQD AVLTYAETRR IRGDMVRRRP SPFLDEIPPE LVEFTTPAKS LKPASPEVAA
NYLAQMKAQF APKKNAAGVG PLPPSTAIDR DRPQR
//
