ID A0A1G1FE86_9BACT Unreviewed; 595 AA.
AC A0A1G1FE86;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Cl-channel voltage-gated family protein {ECO:0000313|EMBL:OGW30040.1};
GN ORFNames=A2X56_10920 {ECO:0000313|EMBL:OGW30040.1};
OS Nitrospirae bacterium GWC2_57_13.
OC Bacteria; Nitrospirota.
OX NCBI_TaxID=1801697 {ECO:0000313|EMBL:OGW30040.1, ECO:0000313|Proteomes:UP000177780};
RN [1] {ECO:0000313|EMBL:OGW30040.1, ECO:0000313|Proteomes:UP000177780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW30040.1}.
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DR EMBL; MHDZ01000007; OGW30040.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1FE86; -.
DR STRING; 1801697.A2X56_10920; -.
DR Proteomes; UP000177780; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 467..525
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 533..592
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 595 AA; 64092 MW; B18C67A6E110E848 CRC64;
MRNMRITLQK LRKFALENLR WLPNFKPGEH TALIIQAFII GILAGLLNIA FRSTMEFVNN
VIFKGGSTLL GVDQGGLHLL LVPLLPMAGA LLLIPLSKGF PGQVNGYGFP QFLETVNIKG
GVIKLRNILL KTLAPALTIG SGGSAGVEGP IAIIGGTVGS GVGQLFKVSG NRMRLLIAAG
CAGGIAATFN APIAGVMFAM EIVLLGNYEL ASFSAIVIAS GIATVISRGH YGAFPAFPVP
QYDLVSMYEI PLYMILGLIV GTLAVLYIRI FYGVRKKFDN LKLHPQLKPV FGAFIVGCIG
IFLPQIMGNG YEFIEDALSG KIILPVIFLL IFFKMGATAV TLGSGGAGGV FAPALFIGAM
TGGTFGLIVH ALFPVQTASA GAYATVGIGS FLSAATHAPL TGIFLLFEMT GNYKIIIPLM
FASIIGTLVA KRLKADSIDT EELTQKGIRI HAGREVAIMS SVKVKDVLHG DIPTVHEHTT
LYELIELMIE KERYHIPVIN EKDEMVGIVS IQDVRPVMFD EDIKRIVRAV DIATEKVITL
GPYDNLNTAM EKFSLKDIDE IPVVDVLYPR KVIGMVSRRD VISAYNKEVL KKQVH
//
