ID A0A1G1JT05_9BACT Unreviewed; 764 AA.
AC A0A1G1JT05;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:OGW83818.1};
GN ORFNames=A3C47_01110 {ECO:0000313|EMBL:OGW83818.1};
OS Omnitrophica bacterium RIFCSPHIGHO2_02_FULL_51_18.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801823 {ECO:0000313|EMBL:OGW83818.1, ECO:0000313|Proteomes:UP000179119};
RN [1] {ECO:0000313|EMBL:OGW83818.1, ECO:0000313|Proteomes:UP000179119}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW83818.1}.
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DR EMBL; MHFI01000010; OGW83818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1JT05; -.
DR STRING; 1801823.A3C47_01110; -.
DR Proteomes; UP000179119; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR000424; Primosome_PriB/ssb.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS50935; SSB; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00252};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..152
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 198..469
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 510..712
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 764 AA; 85397 MW; EA738E22D46FF23D CRC64;
MQALRRRPLF YAAFLISFLI LASPVFPPPF QDIFNRISQD DIYWEVREKE KSVFLGGVII
SEVETRISGY GDPLTGFVLE AKKAWIEQDK GGKKVSGRVK CYLKRLAVPL KYGDEIVIRG
DLRLPPGLRN PGGFDQSVYL ARQRIRTVFY GDKHFNAKLL RRGQTNFVYG KALEAKHFLS
DRLSRAFEKN EAAFLKALFL GERSELEEDF TDLFIKTGTM HILAVSGFNI GFLCAALFLL
LYPFPVPKNV KLLMALITIW LYCAVVGWQA PVVRASLMAS VFFMGQLLGR KADALNSLGL
AACVILVFNP QALFDVGFQL SFLAVFGIVC FVPLFLKRAE LLPHEHKTLK ERVLFYLKEI
FWVSFVCLVV TLPVTVQNFY IVTPLSVLSN LAVVPLSFLL FLAGVLFFLS AAWTHSALGW
IPFLMSGLMK LFVAILKGIE QIPGAYFIVG KLGWPFFLCL VLGISYLLAN KRIKNRTVRA
AVILLFLMNV FCLQEMSRQF NRPFRMTVLD VGQGDSIYFE FPQGGNMLVD AGKGGDGDKG
RRVIAPFLKS KGVRSIDFMI ISHPQEDHIG GLPVLFDEFR IKRLGEAGSE YPTELFHEVK
GKIKKERSQH RILREGGALG EFKGVAVQVL GPAEEWLGRG DVNNESLVLK LTYGSTSFLL
TGDIGKEAMA ALLEKKADLS ATVLKAPHHG AKFKVEGERF VKRVNPKVSV ISVGARNPFH
HPSQMTLDVL SEVSGSQIFR TDRDGAVEIV SDGRHLDVNL PVRS
//
