ID A0A1G1JTC4_9BACT Unreviewed; 413 AA.
AC A0A1G1JTC4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=A2987_06870 {ECO:0000313|EMBL:OGW83897.1};
OS Omnitrophica bacterium RIFCSPLOWO2_01_FULL_45_10.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801826 {ECO:0000313|EMBL:OGW83897.1, ECO:0000313|Proteomes:UP000176340};
RN [1] {ECO:0000313|EMBL:OGW83897.1, ECO:0000313|Proteomes:UP000176340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW83897.1}.
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DR EMBL; MHFL01000042; OGW83897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1JTC4; -.
DR STRING; 1801826.A2987_06870; -.
DR Proteomes; UP000176340; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ SEQUENCE 413 AA; 45235 MW; A72D9C1E694E5CF9 CRC64;
MENKVNSTGE QAWKLEVIER VPHHPADDYK ESFIEKRRRW LLEKAQVECR HISNFSFDPA
EVKGNIENFV GVAQVPIGIV GPIKLQGEYA NGVFYVPFAT TEGAMVSTYQ RGAIAMAKSG
GARTLILKDE QHLEPVFLLE NLTQVRPFLN WLETHFKEIK AEADSTTAHG RLLTITPYVF
GSRVVLDFAY QTEDAMGANM VNIATEKVCH FIVKRQPIKN FLLRSNLTSE KKASAYHLLS
AYGKQVIAET ILPHEIVERY LHSTPEKISS AWRSWAIASL GSGAIGMNAH FANGLAAIFI
ACGQDAAHVA NGCVGLIIFE QTPTGDLYAA VKLSSLLVGT IGGGTGFGTQ RECLELLGCY
GVGKAKKFAE IIAATLLAGE IGICAGITSE EFLDPHKRAR VHTVARAYED AKK
//
