ID A0A1G1JY75_9BACT Unreviewed; 543 AA.
AC A0A1G1JY75;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN ORFNames=A3C35_02075 {ECO:0000313|EMBL:OGW85641.1};
OS Omnitrophica bacterium RIFCSPHIGHO2_02_FULL_46_11.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801820 {ECO:0000313|EMBL:OGW85641.1, ECO:0000313|Proteomes:UP000176909};
RN [1] {ECO:0000313|EMBL:OGW85641.1, ECO:0000313|Proteomes:UP000176909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW85641.1}.
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DR EMBL; MHFF01000051; OGW85641.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1JY75; -.
DR STRING; 1801820.A3C35_02075; -.
DR Proteomes; UP000176909; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 451..478
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 498..520
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 141..325
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 341..533
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 33..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 61379 MW; 3E07EFAE408C22E4 CRC64;
MNSDKRFLLA AAFSFLILLA YPVYLKWISP ETPSKPTQVS PISSETEKID PSPAAQEMER
LVPEKALPEG KSYPFSSNHF QVEFSDRGAV SKLELKSWGK EQKSEVLIDR PPGSSGAFLV
SLPNQGISFN AQEFSPSINE AMGEARFIGE EPGKWRLKKT FRFDQDRPAI YLDVEVENLS
AQKQPALLEV SSQFAGSTKH DKSPIPAEAF VALRDKLVSE HLDKVQKRPY VVEADILWTA
LARKYFVLIT QPDQPAVLVR TTAGPKGTEW MQSAIQFAPV GVEPGSSLKR SFLIYPGPQY
YQTLKSFNQG FEQILSHGFF GLFKLWLLTA LQWAHKVTSN YGWAIILLTC AIKLLFTPLT
HMSFESMKKM QALQPKIKSL QERYKNDQAK LSQETMGLYK QHKVNPMGGC LPMVLQIPIF
IAFYQVLAQT AELKGAPFIF WIKDLSEPDA AWLLPFALPF LGANVNILPL LMLGSMVWQQ
RLTPQTGGTK EQQQMMMFMP IIFGFIFYNL PSGLVLYWFV NNMLSIFHQL FVKGKALPHH
EEV
//
