ID A0A1G1K9W0_9BACT Unreviewed; 713 AA.
AC A0A1G1K9W0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=A3A73_04535 {ECO:0000313|EMBL:OGW89724.1};
OS Omnitrophica bacterium RIFCSPLOWO2_01_FULL_50_24.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801829 {ECO:0000313|EMBL:OGW89724.1, ECO:0000313|Proteomes:UP000179322};
RN [1] {ECO:0000313|EMBL:OGW89724.1, ECO:0000313|Proteomes:UP000179322}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW89724.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MHFO01000024; OGW89724.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1K9W0; -.
DR STRING; 1801829.A3A73_04535; -.
DR Proteomes; UP000179322; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 10..286
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 287..604
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 713 AA; 81957 MW; 385E63FB4E7A40B4 CRC64;
MNSEFERLLG ELNREQMKAV TSPVGALLVL AGAGSGKTRI LTLRAAHLIA NGIPSIHLLG
VTFTNKAANE MKRRVSRLVD HEVWISTFHS TCLKILRVDA FSAGLGTHFS IYDDHDQLVL
IKECLHELGL DAYRQINPKG IREAIQRAKD YLVTPQRYRE RAEDAFEKKV ADVYERYEQR
MGVLNACDFG DLILKTVFLF DRHPEVLEAW QKRFQHILID EYQDTNHAQY RLVRHLTNQS
QNITVVGDPD QSIYAWRGAD IQNILNFEKD YPQARVVKLE QNYRSTSTIL NAANALIACN
VKRKPKELWT EAGRGERISI YEAADEKEEA EFIVREVLRV KQSRGSLADC VVFYRLHAQS
RVLEEVLRAR KIPYRIVGGI RFYDRKEIKD LIAYLKALAY PQDQLSFKRV VNLPNRGIGT
KTISAFEAYQ KSRGVTWNEA LKNVSDLQGI GPRAKESLAQ FGRMMESLKR EKASFLASEL
LQEVVERTGY VKALESERTF ESKVRIENIQ EFFSAVQEFE ENWEPAVEER APKKGVQYRT
DRSVPLLQAA NRRSIEQYRT DRSAKRYEGL LEAFLESISL ITDLDTWDEG SDSVTLMTLH
TAKGLEFPVV FMVGMEEEVF PHVNSLRSDT GELEEERRLC YVGMTRAKEK LVLTYANSHR
LYGIRQHHLP SRFLSEIPSS LFEEVSSFAN SSREADETVV LDLDESKRRI LFD
//
