ID A0A1G1KWR6_9BACT Unreviewed; 7594 AA.
AC A0A1G1KWR6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Histidine kinase domain-containing protein {ECO:0000259|PROSITE:PS50109};
GN ORFNames=A3G33_09285 {ECO:0000313|EMBL:OGW97378.1};
OS Omnitrophica bacterium RIFCSPLOWO2_12_FULL_44_17.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801832 {ECO:0000313|EMBL:OGW97378.1, ECO:0000313|Proteomes:UP000178187};
RN [1] {ECO:0000313|EMBL:OGW97378.1, ECO:0000313|Proteomes:UP000178187}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGW97378.1}.
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DR EMBL; MHFR01000042; OGW97378.1; -; Genomic_DNA.
DR Proteomes; UP000178187; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19879:SF1; CANNONBALL-RELATED; 1.
DR PANTHER; PTHR19879; TRANSCRIPTION INITIATION FACTOR TFIID; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1816..1923
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REPEAT 5496..5539
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 5540..5581
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 5582..5615
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 5669..5710
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 5727..5761
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1598..1617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1858..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2583..2646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3820..3841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3858..3900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4226..4256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4994..5051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5838..5857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5872..5954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6718..6820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4334..4361
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4480..4507
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2620..2635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3820..3840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3858..3884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4229..4250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4994..5015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5016..5031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5032..5051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5842..5856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5889..5904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5921..5944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6718..6744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6778..6806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7594 AA; 859592 MW; 24F4A0CBAE897A3B CRC64;
MWDEFKRKGK REKEKTDSGF SRHCEKGIMS FPRPPHNFGG SANALVVEKR ESSWIPACAG
MTNFLYFFRY RFILTPRFLF KTVAIITLLA FITTNASLAQ SAPAINASAE AVDVKPLTAD
ISIPKELGTI ESQHAGESGA PFVIILQDAH AVVDAQLALQ KLIAYFQKQY GIKIVAAEGA
KGAFDPLLLR TFPDQDTKSK VMMDYLKKGE IAGAEMAALF PTEAGSTSGG NEQEASFYGI
EDWKLYEENY VAYLRAVERR DDILKALGTL RKELDALREK IYSPGLNKFH EQREAFYEER
EGLVEFVRYV SEANQQVDNS TLSKHSVIPA KAGIHEQKNL LQEPANLDPR FSAQQDGGSV
SLIGGRGDDK LAGRLDLYPH LSVLIRSIDQ NESLDPKKMN SELRQMAKNF KEKYSQKLDR
ETLMKVNKSE QAFVTGQLDM GRFLKILAEA GRSAGIELEL PLSMKELLDN SESLAAIKGT
ALFKELEKWI IQTESELVTT SEEKVLVQKF SEIRLAEKLA KLELTHAEWE SLKSPDTGHQ
SLEEKGTGNG SLLSHMPVPF SSLKPFFGPA FEFYRLALER DEALYRNLMK IVGAGLKPAP
TKAAIFIAGG FHTEGLEKAL QTGKNSYVVI SPKIGSLEGA ETYQHVMQGE LSYREYLKTT
FYDAFMNDAT IKLMREQNEP DFRRNLKIWR DDIIRKLASK GRIAEAAKYT RYIDRLVLLY
QQKFAEGKAG LNKDELIQKI SQELNQYTES TLAELWQRFQ GQVNQFTSGL KELAAEKQIN
PANVSQLINR VANVNTSTLS TIHGALVPGL QLPWYPEFAK TGKVPESVIP EVQQDQRRAY
SVEREGGNEQ IKPIKKLSAK RSTLSPNSRS EIRKNNTARI VWENIRKEFE EHDPHIGDKK
EGYLPLLYHK IEKSLLSIAE KIDQSKIDPG ATLKTLKYSP SSAESEQKTV NRELRVGIYP
IAANPMTWGH IMVALMVMDE LNLDTVLIRV QGEIRYKNLR ESDRVPAEDR FQSVQEALKD
LKPLLRLTDI GLHTEAIGEL NAHEIFNMNP DQKIKLVYIS GSETEARTRN IAHNLYDSLR
QNRFGKNPER KMMWALNHRV AKGAENFGET FDQNELDRLM TRSFIEENQN SILRYLKYVP
FPLAVWVRAL LLWLSEFLPF LRAKVFDAYL LHGDLGGSSS SYRVTQDAAT IPRVIHEAAV
AKGYYGNVPG DFEDKLRPIS QQVVDLIKAR LEAMLSSKSG GIVFIDGPSA SGKSTLGKQI
KDLLSLSGSN SVLVGLDMRL KSHEWRHAIQ KQVTGENLTE ADKAVLTEEE KSIQPRKIYL
KEENFFDQAD ILKVLTEIKD FFASDKPSHT IKIPGAYDQK TKEVLPEMTI EIKKGDIVLV
EGKYANREEL AALADFHVRL KDNEERVISR FEKRTRSLSR EDNPQTEADR QVKFYRLSLG
PSYEAYAKRT DQMIDVYVDI SDPDYWYAIP KAHADLMNQL RAGYSDAVQQ KALRDLEKLG
VAAMNVLMQA LTDSDETLRF HAAQLLGRLG KDAGHAVQLL IETLADKSEA VAKEAASTLV
KIGEPAIPLL ETALGNRYSV VQDYAKWALV EMQNTNRSEL REDGAAQPPT PSNPAPVVRS
FEQVLHDFME GYDSRFENPV LQNDPEKLRV VIEFISRRQM VHELRSLILG GVQFIYGHKG
SSKIITENNL IKQEKLFEEM FRLEEALDLV GSLGGSAEGR QKLVRLVART MQLVQETLDL
TRDFLKVHPE ELKLLSGTNL RLEEILKDMD GALKEEISID DLLSILSDAP AKFSGLLMEI
GDIDFFKNLK ISYADFKDLL TNLYKNAWEA MKQEPNAGIV IKTDAKVVNG RLKLTVTDNG
QGMPQDKADK INRGEAVQSS KGDGRGMGVG IMMGVVKKYG GTIHVTPIEN EGTIFEIELI
PKSEKDKTEQ KQVVVTQQGD AARAEVRMKN SFESRVPNSG LGQGGQLGTL NSELETQPRA
EVRNKNQSIG ELLPENMSLI DDPVLIRASW GSREDIQTSL EEVKSYMKRD ARYSRKVWIA
FALSFPEAQD AIKKMEPEYH EQAEQLLNYL IEVVQKTKSV VDDGFVRLDP SNIHQFMWGA
PAANSSILDR LGIVDKLTGK IVNQKRMSSF GLNPDSRVGE RWLVSDDTEF PSWVVMEGFP
IPLFWLISQY PRDVLGEKHA EAYRDSLGAV LKYLEVRDNL SLQIHRNISE GFYFLEVSQN
AGFFLGLNEP ASESQRLMMV KHVVARLKNR DSKVIREPPY KMDHLDGDVL HRLPEVNVDT
VADYLLKGDS QATFMLELAT QGMFKPTIGH FGINEQSEIG QVVGTLLLDG MHFVDIVGFG
LDAQGHLDPA MSLLKFHQPK PDDRFVIRQH TLHALRGVPD QSMLLFEFRD TAAVWPFRRQ
PEDLTSRQTI SLADNVSGRV ERPGKVIGEI LPQALIYWTD RDGEKPGRYW HRGDERYRRI
GRTKGAETMM MFRNWKFYGR SIRLESGAAV KLIRHGQHSA FLVQSGTVEI RDVNGKMLGT
AGREEEILIS AKKGDLILKA TGSEPVQLVE FKRPVPGVPI PEVVSLQRRR APKSTVLVEW
NPRSETRHTE KNNGVIPAGA GIQQLDPHFS AKQRGRIRQR FSGGRGDDNR FEANAARSEA
RSQLSQDGLS VEEKKIILGS KAKEYKSSTR DSYFNVFGNN YFSPFNSPAV FSGRDQPAVE
VNGKDILILP ADNNLPFILM KHNPGPNSII VVDINPATIA WQKALFLHSG KKPLSNLLSE
DDFEPLKAAQ LVRFYVAKDE APAPSRKNLM AKVANIVEGL PFPDNSFDSA IVRWLFGAPT
GIMSKEQVAT AFRELLRVAR PGAKILIEPS SYDDYSMFGG SDFDEEKTLT PDEFSKLTYG
SKQVEVVDNA TFWDGERMMT VFNVVEKKEL LVNVTLSESH LEGDTQARSE IRSDIVSVIR
EHFNGQDTIS FVDLDTGDGS FVTRFAQLLR SYFPEVNGMG METFRWLVDQ ARGLGHNVYH
GNAQIEEDYI QAGLADESKE IVTINNIESA PEALIRQADR ILKSDGLLMI TFEEGDIMEN
QGIDRSVQQM LEEKGYKIEI IKPISKDYPR TLAYWKEADF ILLATKPRSE VRNLNTYRML
QQPITIDDLR RFHDDQTPIQ VSSKGGRNVV AKVREFNIWA DDEFSVPAFS LTLDFYDSLQ
IEPDKRLGFV LIAADSYREE GLDDIEIPRI ELHQAEYSNS GIGRWAMELI HNLSRPDANL
FVRTHSPLLF HLIRQYFFSE DLEISISEEF QSEINDVRMA ITAFEANRKY GDGSHIAMLR
NGIFDFSKSE MPAYRDLFAK LEVGSDGRLR VFDKVGNEIP GLAFRFGSAI DVRGMRRNEI
VFPAKSDSVT ARGEVRMKNS SESRVPSSGL SQRDQLGTLN SKLETQFRAE VRQNIFDGVF
LLNGLKTDEL LFEVSGGESL TLNGKPVRTI HISAVTGAIA YENPPFPELP LTEPVSYRVE
SEAKIGVLTE EMKQKLIRTI EARLRQTQAP KDGKKVMEAV VLNTALKILN QPVLRLAAES
TVTAEAQSVN LLSASVFSPE EMDTLQTRGK LLKAVYPRLS EQPKAAMLYP TFLLVFMGMK
PAYMEYPNEP NMDALINELN RIGNLGSQAD LMLQPRSVFS LKNIGIRIAH EEAFLEEIGL
LGEKDKPLVD ALEVELKKQN SNQIDRDQFK AISHELLAVM FERFASQEAD GDSLIGFVLG
YPVENLRAFR DWKQARFSKR KSGNPIKFIP GHYIKIGLRS YADPESVKRT EAYLSKLELA
LDYAYGLLTD QSDASAIIDR YKFRIDSPAD LERLVGDLGL GDRSLENGEE PERSEARIKN
SSESRVLSFG LGQRDQLGTL NSKLETQPRA EARYSRNNPE QSSIETRKSP RETQEAQARA
EVRSQTEYAI DWSNVKVSTL SAKLSGQQDQ YIHDMTLKFQ SARTLRVKNQ LRRIVAAEVM
RKRNALDKIP SQTIQDLFEL EYALRFLEAD WKRLSILDPV RVQSVLKLRK QIPPLPGDRE
MWFGARVDNA RILTRALPVI HIPEDIVTRI EKIFMNENNL DVRVKLQKLR GKLGRIVPFL
NGVFRMEESR LKFSLDNPIQ GEGKLENAEV LRFFPEGVEA FRVKPGWEEI QPLKLAGKEE
DWLDRFLHHV DEAPELESMG FIHDPEFLAK LSDTVDAWLE IVKGAKFRGD SGVRGVGSAQ
ARYTALNTAL RKAQRFLSQY ASGPTKLRLA SPDEDETSGE GPRSEARQSG SDKNKGSSLN
LYLAFDELQY KEMTDKAREE KIAFIFNHLD LMRTEDQRFF ISYIARWIVM GNRKAFLINN
PLLDKSKRDF APRIALLKQR IREYEQELRE LGGNESRAEA RSTPIKLSTL SGGALRPRSE
ARADFSLEIG ELEALRRREI EKEKGALKST DLASLGLAIR QLQSGEQDPN QAILAVRTLE
IAFQGENKNW SKDLSIEITI SLRKVIDGVW AKLGWDEKKL YEMMEALNRI EKLLEEEEND
WQEIKVRYDR ILPLFAADQS KLLELWNIPG RPAELYGSLH PLLMLTHHYE NAAFAHFEVY
KNRPDELRKN TQDANRVRWY FEQIARLIDQ ADSEFSTMDR DQISQQGILS THEQFKRHFL
ALLKRHVQEF QVPISEYELR TFVLKCLKAP DSLDKALRVE FNSLLDELGA LNYLKMGELA
ESFQTLAGRY EELIKAADKK WILSETRDRV QIAQKIAEDF AGFAIDPKDE ARKVYGQMRR
SSIQRKILNR LSPVLAAHQE LLQSGLEEIY LKIDLEEKNR LRNQFHASDV HAAVLAYLPE
ALRPLFNLVI QTIVKRQPED IFVHQAGFRL EYFFGQINLN ARSADLLKDL NLVAYAAWEI
FQALPQVVAG ARSEARKISD KASVVRHKNL TYALSLKPEF SRAEARNTPM RLDVTFQGTP
YRFEMDSWSV GQNPSQYRFR LSQGVQHRGY LIVDYDQQTI GWEGKEQFPR GTLMDPFLKV
AYEALKVDEN KRSEVRMKDS SEFRGKTKRS TRNFKLETQP RAQVRNNKDS SKQLPIETDE
SPRETQEAQA RAEARGIEQQ LVGTFLQMAL FHIQDNASLA VIIEGPAPRT FFEDQDQPEA
VVNRAIGLLQ SIYDQVRRES PDGSGAPFIV RMMEILGRPT ELLPMDLAAA KKYFASSGEV
AEIKSEKKFD QFEALMPGWL AKHPPFLSQL ISELPPMDEI QRKHGAAQIH TENRYAAGPM
KLLEWSVLFA GSPLRPIYYY FDSDPESGDI DSVTEVVFDL AAYLKRGKSG AHTLISSEEI
GSLFKQLGRS EGATRWVMTA SSPGSWQSRI SVTPSAQGMM IKIDDNHLEF DPNTPDDEDG
NKLINFLRQY GIEEPFFGLP FPKHDAATTE IAQFLADVFK ARDALLRKWR IRASFDQSSG
RVTYEAEGET VSTDFGYQVP ILSDNGVVTG TTKGPVEAEI KDFLMKLGID FKPYAQGLTI
QMTIGNENYD LDVIHHLPIT LVKLAEALEA KSKMPFSGHG RTVPALGVLN QAGAVQLVTG
SLDKTVRLWD LSTGKESKKF EGFADEVTDV TVSRDGQKVA AASKDGTVRI WNVQSDSEPI
VIDTLSGPLT SIDFSFDGQR ILTGSKRGAL QLWDVLIGRF VDDLPIKART IFDAQFSPDG
QRMASLSHSM EDGLKLSIWD VPQKKIIRTL DHEAYLQTFA FHPNGKWLVT GDQDYQVCLW
DIETGSKLRT YQSAVKPFAV VNIQPRILSL AFSPDGKLVA AGKLDGSIEV WDVETGGSRY
LFQNLPFNVP TLTFAPDGQS LIYSGYRHND TFFAPMPRII DLRRYPQTFV SHRYGRSVSN
DVRHFVSGGQ DITRSEVREE EVAVGSQQST DVIARSGSDE AISDLGIASA TPGSRLAMTG
KSRAEAREGS AQVQKSTRAQ ENTETYAPIP GAPVLLRSSR SESRADVDPR VSSERHRGSR
QRGDKGSRPS SQMTNGNEYQ FALPKYFSFP GFSLHGAMDV VDFQQVFGFG GQFSFGLQME
ELDKIFESFR KRIFSRVEKF QQFFSRAIAQ DAFCAFVLAG NAFFGLPFLR PKISLVWINS
RTAFQEDRKP QHLLSFRLGQ LLKNDRQNFM SFLRFHVQNL NTALHFIQQE LTARLEISGD
MVNGTTNYHQ PLITNHGQVR AEARNLAAEN GTFSAIPIEA GKSTFDVLPE ASKRAEARKS
VILSSGRNGN TQIDMLNMGE RNPAARVEDL QTEHAPVFSD VHDNTVPDFN RFSDLSGLKS
YVERIRFFIK FYFHRLTLFL EPISRYQNRL IRFLFVDDFQ NVIIETLSRQ ISSSMSFFGV
IGTGYRFFDL ALTQIPLQNP FLDMFRVSES HEYQLPLLKN RQHNKPEMTN NQYNYAAKST
RSEARHAEDS TQEVFNQSAQ MSSIPSKLFT SRAEARNLEA ENGTFSATPI EAGKSTFDVS
TETSKRAEAR MLKGFNTEQK AIIEKTAHKL IMLFFSDKSV TEQNALEKDL ISRIHPATLR
RVIFSKTTLM TISWTLCISV LPFVFHLYKL VAVFGFFGLF ALGKILDQTL NEETLGFVSK
AYPEIFIGTE LPGFKFERGV IHEMLHVLAK MKKIKYDSPF ASAFGFLAEH TSSDPGKPQL
SPYLRRPVGN LGEGMALVEK NLSPQERWGA LIAKSLFSDN SENITKQDPR DFFVSLAHWL
EPETRESRVL GELLSGMAYA LSQKNWFGLE DAWVYLARMA KGEHPFAVEE DLNNKQKERI
SHSKFRSEAR QESAQEHKRT GTQVEMKADA PVPYAPMLLR SRAEARYSRN NPEQSSIETR
KSPRETQEAQ ARAEVRDDKD SLKRSSIGSA RESSIRSEGL VSRAEARTIS EQKRFSLTLE
HVKPLIERIA DTAYFRWLAR DKDSRTGKNE GFEKVQWRRL IDISDRAWDL ESMRREALGQ
LEKSNMNPEY LEKIKSETKI EIIILEYFEE VLGSLIGKLE SPLKLSLKMF LLKAYPRSGE
WTDSLLEEGA IEAARKEYYD IINEILKWLD PTSVLERVNS PEDYRIDVLG RPKDGDIPRM
VDFRGKLIAR EKKAKHRAPF AFRNERFDTM IQIGPQGLEE EEMRFLQSAF DEKPETDSAP
TFYAVFFPPF SYLLIRRSVI KQRVVFDVVP GRWEKAVPNP KKMLPFFIKR VIDYYQLLDN
RKPPQILLEL ATIPMHWNER KVLFEESYFE PGDPDFRSAA TTYPVHFENV LRKIRSRSEA
RHLEDSNDVI PAKAGIQLDP HFRGDDTDSR AEVRSQIEKT KPESPMDLVF ETLDPQKIAA
QIAASKYIEG ELGELSAQVT KTGQGKLDSA KVELGAFSKN LITEINKRSE VRQIADFIFS
DEIEQMAKDR VNLSFPHAVS GNLWIPAFAG MTDVLINRAR LVVFNSVIGE NIAMADEALP
ALSEISSEAA FLLAHPDILN EAYRIKFGKR TDNATIRADH EWIIGMEFLP QASDPRRMAA
EQFLRNLVQA KDRVALTYQK NSPYADMASE LSQSIPQLSL VGHRSDLDQK RFERVFGISY
PFVIVSDSVP FKTSTWRKNG VRINPYMALR LKLEFSQFIR LTQFAVEAGL LRKQIEEISG
VFPELTPEIL NSAIDLLNEL AQTELVRQAI NRAA
//
