ID A0A1G1LP28_9BACT Unreviewed; 336 AA.
AC A0A1G1LP28;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=Hemolysin {ECO:0008006|Google:ProtNLM};
GN ORFNames=A2Z88_04015 {ECO:0000313|EMBL:OGX06945.1};
OS Omnitrophica WOR_2 bacterium GWA2_47_8.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801840 {ECO:0000313|EMBL:OGX06945.1, ECO:0000313|Proteomes:UP000178620};
RN [1] {ECO:0000313|EMBL:OGX06945.1, ECO:0000313|Proteomes:UP000178620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGX06945.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MHFY01000110; OGX06945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1LP28; -.
DR STRING; 1801840.A2Z88_04015; -.
DR Proteomes; UP000178620; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF4; UPF0053 PROTEIN SLL1254; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; CNNM; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 57..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..181
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 265..322
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 336 AA; 38082 MW; 710917A124274DE0 CRC64;
MLSLIILIAG VLLSSALMSM MEAAILSLPL IRARVLLEEN RRNSRLLFEI KTHIHMTVAV
IVIINNAINI CGSIFIGERV TKIFGDQWLG LSAGVMTFTI IIIGEIIPKI IGERYKVRLS
LFFAPLLTAL VVVFGPIAKL ILYLEKPLTR HFKMPSPRVT EEEIKLMLQF GRDAGTVEMD
EEVLCSRVFK LNDLKAYQIM RAIDEAYALP ADKTLQEVKD SIIDSRFSRI VVYGKEPVDI
IGVAQQSVLL REMAKDNYNA KVQEFMAKPV YVNWFTKADE LLEKFQVYNQ HLFIVQDSGG
KNVGIVTMED VLEELFGEIY DEKDIKPKIL TDQQLS
//
