ID A0A1G1NFX9_9BACT Unreviewed; 349 AA.
AC A0A1G1NFX9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=A3B78_02965 {ECO:0000313|EMBL:OGX28541.1};
OS Omnitrophica WOR_2 bacterium RIFCSPHIGHO2_02_FULL_67_20.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1801860 {ECO:0000313|EMBL:OGX28541.1, ECO:0000313|Proteomes:UP000180285};
RN [1] {ECO:0000313|EMBL:OGX28541.1, ECO:0000313|Proteomes:UP000180285}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGX28541.1}.
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DR EMBL; MHGT01000036; OGX28541.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G1NFX9; -.
DR STRING; 1801860.A3B78_02965; -.
DR Proteomes; UP000180285; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 108..328
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 349 AA; 38888 MW; FDF683DF5893422D CRC64;
MSVTDFEQRR KEILGLIIEA YVLSASPVGS ELVSKKLRSS LSSATIRNIM VELEKSGYLE
QPHTSAGRVP TDRGYRFYVD AVMDTAHLSP DELRQIEVLI QPPELDVEQL LQRASGVLAG
LTEQAAFAVS PTVKQRTVKQ IELMPLGVRK ILCVLVANEE MIASHVVEIE EPMSRDEAAA
LGRFLNTELA GLAFSELLNS LERRMLAESD SFYHLVKRSL GILQHALSSE PNDRLYLEGA
SYVVAQPEFS RHPRKAHELL KGLDNEQTLL ERIRQDIAPE GVQVRIGREV QLPGLEECSY
LTAPCAIGEE IVGGLGVLGP KRMSYRRMRA LVEGMARCVT NLLTQWDTR
//
